Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C

X Zhou, KF Benson, HR Ashar, K Chada - Nature, 1995 - nature.com
GROWTH is one of the fundamental aspects in the development of an organism. Classical
genetic studies have isolated four viable, spontaneous mouse mutants1 disrupted in growth …

In vivo modulation of Hmgic reduces obesity

A Anand, K Chada - Nature genetics, 2000 - nature.com
The HMGI family of proteins consists of three members 1, 2, HMGIC, HMGI and HMGI (Y),
that function as architectural factors 3, 4, 5 and are essential components of the …

An HMG-like protein that can switch a transcriptional activator to a repressor

N Lehming, D Thanos, JM Brickman, J Ma, T Maniatis… - Nature, 1994 - nature.com
ONE protein can activate some genes and repress others in the same cell1. The Drosophila
protein Dorsal2 (which, like the human protein NF-κB3, is a member of the Rel family of …

High level expression of the HMGI (Y) gene during embryonic development.

G Chiappetta, V Avantaggiato, R Visconti, M Fedele… - Oncogene, 1996 - europepmc.org
The HMGI protein family includes three proteins, named HMG-I, HMG-Y and HMGI-C. The
first two proteins are coded for by the same gene, HMGI (Y), through an alternative splicing …

The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice

S Calogero, F Grassi, A Aguzzi, T Voigtländer… - Nature …, 1999 - nature.com
Abstract High mobility group 1 (HMG1) protein is an abundant component of all mammalian
nuclei, and related proteins exist in all eukaryotes 1, 2. HMG1 binds linear DNA with …

Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts

M Fedele, MT Berlingieri, S Scala, L Chiariotti… - Oncogene, 1998 - nature.com
Overexpression of the high mobility group I (HMGI) proteins is often associated with the
malignant phenotype. Moreover, many benign human tumors, mainly of mesenchymal …

Cloning of cDNAs coding for human HMG I and HMG Y proteins: both are capable of binding to the octamer sequence motif

R Eckner, ML Birnstiel - Nucleic acids research, 1989 - academic.oup.com
In human B lymphocytes and placenta HMG I and its smaller isoform HMG Y are encoded by
two distinct but structurally highly similar mRNAs which arise most likely by alternative …

HMG has DNA wrapped up.

DMJ Lilley - Nature, 1992 - search.ebscohost.com
HMG has DNA wrapped up. Sign In Folder Preferences Languages New Features! Help
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HMGI-C expression patterns in human tissues. Implications for the genesis of frequent mesenchymal tumors.

P Rogalla, K Drechsler, G Frey, Y Hennig… - The American journal …, 1996 - ncbi.nlm.nih.gov
Cytogenetically visible aberrations of chromosomal region 12q14-15 in a variety of frequent
benign human tumors reflect rearrangements of the HMGI-C gene. The mechanisms by …

The expression pattern of the Hmgic gene during development

U Hirning‐Folz, M Wilda, V Rippe… - Genes …, 1998 - Wiley Online Library
The technique of RNA in situ hybridization to mouse embryo sections from different
developmental stages was used to perform a detailed analysis of the expression pattern of …