[HTML][HTML] Metabolic characteristics of evodiamine were associated with its hepatotoxicity via PPAR/PI3K/AKT/NF-кB/tight junction pathway-mediated apoptosis in …

Q Fan, R Liang, M Chen, Z Li, X Tao, H Ren… - Ecotoxicology and …, 2024 - Elsevier
Evodiae Fructus (EF), an herbal medicine, possesses remarkable anti-inflammatory and
analgesic properties. It exhibits insecticidal activity as a potent insecticide candidate …

Molecular mechanisms of hepatotoxicity induced by compounds occurring in Evodiae Fructus

C Yan, T Peng, T Zhang, Y Wang, N Li… - Drug Metabolism …, 2023 - Taylor & Francis
Evodiae Fructus (EF) is a common herbal medicine with thousands of years of medicinal
history in China, which has been demonstrated with many promising pharmacological …

Elucidation of the relationship between evodiamine-induced liver injury and CYP3A4-mediated metabolic activation by UPLC-MS/MS analysis

T Peng, J Rao, T Zhang, Y Wang, N Li, Q Gao… - Analytical and …, 2023 - Springer
Evodiamine (EVD), which has been reported to cause liver damage, is the main constituent
of Evodia rutaecarpa (Juss.) Benth and may be bioactivated into reactive metabolites …

[HTML][HTML] Integrated spatial metabolomics and transcriptomics decipher the hepatoprotection mechanisms of wedelolactone and demethylwedelolactone on non …

P Chen, Z Zhu, H Geng, X Cui, Y Han, L Wang… - Journal of …, 2024 - Elsevier
Eclipta prostrata L. has been used in traditional medicine and known for its liver-protective
properties for centuries. Wedelolactone (WEL) and demethylwedelolactone (DWEL) are the …

[HTML][HTML] Evaluation of the cardiotoxicity of evodiamine in vitro and in vivo

W Yang, L Ma, S Li, K Cui, L Lei, Z Ye - Molecules, 2017 - mdpi.com
Evodiamine is a bioactive alkaloid that is specified as a biomarker for the quality assessment
of Evodia rutaecarpa (E. rutaecarpa) and for traditional Chinese medicines containing this …

[HTML][HTML] Maintaining calcium homeostasis as a strategy to alleviate nephrotoxicity caused by evodiamine

C Yang, C Lai, J Pan, J Gao, B Shen, Y Ru… - Ecotoxicology and …, 2024 - Elsevier
Evodiamine (EVO), the main active alkaloid in Evodia rutaecarpa, was shown to exert
various pharmacological activities, especially anti-tumor. Currently, it is considered a …

Emodin-8-O-β-D-glucopyranoside-induced hepatotoxicity and gender differences in zebrafish as revealed by integration of metabolomics and transcriptomics

T Han, W Xu, X Wang, J Gao, S Zhang, L Yang… - Phytomedicine, 2024 - Elsevier
Abstract Background Emodin-8-O-β-D-glucopyranoside (Em8G) is an active ingredient of
traditional Chinese medicine Rhei Radix et Rhizoma and Polygonum multiflorum Thunb …

CYP3A4 inducer aggravates big flower Evodiae Fructus-induced hepatotoxicity whereas limonin attenuates its hepatotoxicity

W Zhang, M Wang, H Song, C Gao, D Wang… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Evodiae Fructus (EF), the traditional Chinese
medicine, has been typically used to treat headache, abdominal pain, hernias, and …

The Toxicity and Metabolism Properties of Herba Epimedii Flavonoids on Laval and Adult Zebrafish

R Zhong, Y Chen, J Ling, Z Xia, Y Zhan… - Evidence‐Based …, 2019 - Wiley Online Library
Zebrafish is being increasingly used for metabolism and toxicity assessment. The drugs
consumed in zebrafish metabolism studies are far less than those used in rat studies. In our …

[HTML][HTML] Toxicity of Evodiae fructus on Rat Liver Mitochondria: The Role of Oxidative Stress and Mitochondrial Permeability Transition

Q Cai, J Wei, W Zhao, S Shi, Y Zhang, R Wei, Y Zhang… - Molecules, 2014 - mdpi.com
Evodiae fructus (EF) has been used in China for thousands of years as an analgesic,
antiemetic, anti-inflammatory and antidiarrheal drug. EF is a toxic drug and causes …