[HTML][HTML] B cell follicles and antigen encounters of the third kind
JG Cyster - Nature immunology, 2010 - nature.com
Defining where and in what form lymphocytes encounter antigen is fundamental to
understanding how immune responses occur. Although knowledge of the recognition of …
understanding how immune responses occur. Although knowledge of the recognition of …
[HTML][HTML] Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells
TG Phan, I Grigorova, T Okada, JG Cyster - Nature immunology, 2007 - nature.com
The mechanism of B cell–antigen encounter in lymphoid tissues is incompletely understood.
It is also unclear how immune complexes are transported to follicular dendritic cells. Here …
It is also unclear how immune complexes are transported to follicular dendritic cells. Here …
[HTML][HTML] B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node
YR Carrasco, FD Batista - Immunity, 2007 - cell.com
Adaptive B cell responses are initiated by B cell receptor–antigen engagement. Despite its
importance, the early stages of B cell interaction with antigen in vivo remain elusive. Using …
importance, the early stages of B cell interaction with antigen in vivo remain elusive. Using …
The who, how and where of antigen presentation to B cells
FD Batista, NE Harwood - Nature Reviews Immunology, 2009 - nature.com
A functional immune system depends on the appropriate activation of lymphocytes following
antigen encounter. In this Review, we summarize studies that have used high-resolution …
antigen encounter. In this Review, we summarize studies that have used high-resolution …
Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells
In contrast to naïve T cells that recognize short antigen-derived peptides displayed by
specialized antigen-presenting cells, immunoglobulin receptors of B lymphocytes primarily …
specialized antigen-presenting cells, immunoglobulin receptors of B lymphocytes primarily …
Visualizing B cell capture of cognate antigen from follicular dendritic cells
The prominent display of opsonized antigen by follicular dendritic cells (FDCs) has long
favored the view that they serve as antigen-presenting cells for B cells. Surprisingly …
favored the view that they serve as antigen-presenting cells for B cells. Surprisingly …
B cell migration and interactions in the early phase of antibody responses
T Okada, JG Cyster - Current opinion in immunology, 2006 - Elsevier
In the early phase of thymus-dependent antibody responses antigen-engaged B cells
rapidly change their localization within the secondary lymphoid organs to access helper T …
rapidly change their localization within the secondary lymphoid organs to access helper T …
[HTML][HTML] The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles
KA Pape, DM Catron, AA Itano, MK Jenkins - Immunity, 2007 - cell.com
The initial step in a humoral immune response involves the acquisition of antigens by B cells
via surface immunoglobulin. Surprisingly, anatomic studies indicate that lymph-borne …
via surface immunoglobulin. Surprisingly, anatomic studies indicate that lymph-borne …
Antigen presentation by dendritic cells for B cell activation
Highlights•B cells preferentially respond to membrane-associated antigens.•Two main cell
types, macrophages and follicular dendritic cells, implicated in presentation of native antigen …
types, macrophages and follicular dendritic cells, implicated in presentation of native antigen …
Trafficking of B cell antigen in lymph nodes
SF Gonzalez, SE Degn, LA Pitcher… - Annual review of …, 2011 - annualreviews.org
The clonal selection theory first proposed by Macfarlane Burnet is a cornerstone of
immunology. At the time, it revolutionized the thinking of immunologists because it provided …
immunology. At the time, it revolutionized the thinking of immunologists because it provided …