In the recent years, there has been an increasing amount of single-cell sequencing studies,
producing a considerable number of new data sets. This has particularly affected the field of …

Background Effective management and treatment of cancer continues to be complicated by
the rapid evolution and resulting heterogeneity of tumors. Phylogenetic study of cell …

Studies of gene expression in cancerous tumors have revealed that tumors presenting
indistinguishable symptoms in the clinic can be substantially different entities at the …

Background. Single cell sequencing (SCS) technologies provide a level of resolution that
makes it indispensable for inferring from a sequenced tumor, evolutionary trees or …

Recently, an increasing number of studies sequence multiple biopsies of primary tumors,
and even paired metastatic tumors to understand heterogeneity and the evolutionary …

Single-cell sequencing (SCS) now promises the landscape of genetic diversity at single cell
level, and is particularly useful to reconstruct the evolutionary history of tumor. There are …

Single-cell sequencing enables the inference of tumor phylogenies that provide insights on
intra-tumor heterogeneity and evolutionary trajectories. Recently introduced methods …

Computational methods have been developed to reconstruct evolutionary lineages from
tumors using single-cell genomic data. The resulting tumor trees have important applications …

A new generation of scalable single cell whole genome sequencing (scWGS) methods
allows unprecedented high resolution measurement of the evolutionary dynamics of cancer …

Recent improvements in next-generation sequencing of tumor samples and the ability to
identify somatic mutations at low allelic fractions have opened the way for new approaches …