Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission–experience on safety and efficacy within a randomized …

CM Wendtner, M Ritgen, CD Schweighofer… - Leukemia, 2004 - nature.com
Patients with CLL responding to initial chemotherapy with fludarabine alone (F) or in
combination with cyclophosphamide (FC) were randomized for treatment with alemtuzumab …

Consolidation with alemtuzumab improves progression‐free survival in patients with chronic lymphocytic leukaemia (CLL) in first remission–long‐term follow‐up of a …

CD Schweighofer, M Ritgen… - British journal of …, 2009 - Wiley Online Library
Alemtuzumab has shown considerable activity in untreated and relapsed chronic
lymphocytic leukaemia. We report our long‐term experience in 21 patients within a …

Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia

P Hillmen, AB Skotnicki, T Robak, B Jaksic… - Journal of Clinical …, 2007 - ascopubs.org
Purpose We conducted a randomized trial to evaluate the efficacy and safety of intravenous
alemtuzumab compared with chlorambucil in first-line treatment of chronic lymphocytic …

Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine

KR Rai, CE Freter, RJ Mercier, MR Cooper… - Journal of Clinical …, 2002 - ascopubs.org
PURPOSE: This phase II pilot study determined the efficacy and safety of alemtuzumab
(Campath-1H; Burroughs Wellcome, United Kingdom) in patients with chronic lymphocytic …

Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: clinical results and prognostic marker analyses from the CLL2H study of the …

S Stilgenbauer, T Zenz, D Winkler, A Buehler… - Journal of Clinical …, 2009 - ascopubs.org
Purpose The phase II CLL2H trial evaluated safety and efficacy of subcutaneous
alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia (CLL) …

Alemtuzumab as consolidation after a response to fludarabine is effective in purging residual disease in patients with chronic lymphocytic leukemia

M Montillo, A Tedeschi, S Miqueleiz… - Journal of clinical …, 2006 - ascopubs.org
Purpose Treatment with alemtuzumab has resulted in negative responses for minimal
residual disease (MRD) in patients with chronic lymphocytic leukemia (CLL). In a prior …

Frontline low-dose alemtuzumab with fludarabine and cyclophosphamide prolongs progression-free survival in high-risk CLL

CH Geisler, MB van t'Veer, J Jurlander… - Blood, The Journal …, 2014 - ashpublications.org
Abstract The randomized Haemato Oncology Foundation for Adults in The Netherlands 68
phase 3 trial compared front-line chemotherapy with chemotherapy plus the CD52 …

Fludarabine plus alemtuzumab versus fludarabine alone in patients with previously treated chronic lymphocytic leukaemia: a randomised phase 3 trial

T Elter, L Gercheva-Kyuchukova, H Pylylpenko… - The lancet …, 2011 - thelancet.com
Background Chronic lymphocytic leukaemia (CLL) is an incurable and chronic disorder, with
worsening prognosis for patients as their disease progresses. We compared the efficacy and …

Eradication of minimal residual disease in B-cell chronic lymphocytic leukemia after alemtuzumab therapy is associated with prolonged survival

P Moreton, B Kennedy, G Lucas, M Leach… - Journal of Clinical …, 2005 - ascopubs.org
Purpose To test whether eradication of minimal residual disease (MRD) in B-cell chronic
lymphocytic leukemia (CLL) by alemtuzumab is associated with a prolongation of treatment …

Consolidation therapy with subcutaneous alemtuzumab after fludarabine and rituximab induction therapy for previously untreated chronic lymphocytic leukemia: final …

TS Lin, KA Donohue, JC Byrd, MS Lucas… - Journal of clinical …, 2010 - ascopubs.org
Purpose To determine if alemtuzumab consolidation improves response rate and
progression-free survival (PFS) after induction chemoimmunotherapy in previously …