C-terminal determinants for RNA binding motif 7 protein stability and RNA recognition

AM Sobeh, CD Eichhorn - Biophysical chemistry, 2023 - Elsevier
The 7SK ribonucleoprotein (RNP) is a critical regulator of eukaryotic transcription. Recently,
RNA binding motif 7 (RBM7) containing an RNA recognition motif (RRM) was reported to …

Structural and dynamic studies of the human RNA binding protein RBM3 reveals the molecular basis of its oligomerization and RNA recognition

S Roy, S Boral, S Maiti, T Kushwaha… - The FEBS …, 2022 - Wiley Online Library
Human RNA‐binding motif 3 protein (RBM3) is a cold‐shock protein which functions in
various aspects of global protein synthesis, cell proliferation and apoptosis by interacting …

Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7

E Uchikawa, KS Natchiar, X Han, F Proux… - Nucleic acids …, 2015 - academic.oup.com
The non-coding RNA 7SK is the scaffold for a small nuclear ribonucleoprotein (7SKsnRNP)
which regulates the function of the positive transcription elongation factor P-TEFb in the …

RNA recognition motifs: boring? Not quite

A Cléry, M Blatter, FHT Allain - Current opinion in structural biology, 2008 - Elsevier
The RNA recognition motif (RRM) is one of the most abundant protein domains in
eukaryotes. While the structure of this domain is well characterized by the packing of two α …

Structural basis for RNA recognition by the N-terminal tandem RRM domains of human RBM45

X Chen, Z Yang, W Wang, K Qian, M Liu… - Nucleic Acids …, 2021 - academic.oup.com
RBM45 is an RNA-binding protein involved in neural development, whose aggregation is
associated with neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) …

RRM–RNA recognition: NMR or crystallography… and new findings

GM Daubner, A Cléry, FHT Allain - Current opinion in structural biology, 2013 - Elsevier
To characterize protein–RNA recognition at the molecular level, structural biology has
turned out to be an indispensable approach. Detailed and direct insights into the mechanism …

Global profiling of Rbm24 bound RNAs uncovers a multi-tasking RNA binding protein

Y Lin, KT Tan, J Liu, X Kong, Z Huang, XQ Xu - The International Journal of …, 2018 - Elsevier
RNA binding proteins serve as critical molecular switches in a multitude of post-
transcriptional regulatory processes. In the heart and muscles, the tissue specific RNA …

Structural characterization of RNA binding to RNA recognition motif (RRM) domains using data integration, 3D modeling and molecular dynamic simulation

H Dhondge - 2023 - theses.hal.science
This thesis was carried out in the frame of a larger European project (ITN RNAct) in which
computer science and biology approaches were combined to make progress towards the …

Solution structure of the second RRM domain of RBM5 and its unusual binding characters for different RNA targets

Z Song, P Wu, P Ji, J Zhang, Q Gong, J Wu, Y Shi - Biochemistry, 2012 - ACS Publications
The RNA binding motif protein 5 (RBM5), also known as LUCA15 or H37, containing two
RNA recognition motifs, is a component of the spliceosome A complex. Previously, it has …

The RNA recognition motif domains of RBM5 are required for RNA binding and cancer cell proliferation inhibition

L Zhang, Q Zhang, Y Yang, C Wu - Biochemical and biophysical research …, 2014 - Elsevier
RBM5 is a known putative tumor suppressor gene that has been shown to function in cell
growth inhibition by modulating apoptosis. RBM5 also plays a critical role in alternative …