The informational content of genomes is usually interpreted as a sum of one-to-one
relationships between nucleotides at certain genomic positions and phenotypic outcomes …

Epistasis describes non-additive interactions which affect gene expression and phenotype. It
can happen on multiple levels, including on a genomic level with interactions between …

Since Bateson's discovery that genes can suppress the phenotypic effects of other genes,
gene interactions—called epistasis—have been the topic of a vast research effort. Systems …

Epistasis is a phenomenon whereby the effects of a given gene on a biological trait are
masked or enhanced by one or more other genes. A new study documents epistasis among …

The structure, function, and evolution of proteins depend on physical and genetic
interactions among amino acids. Recent studies have used new strategies to explore the …

Epistasis is an interaction among genes that makes the phenotypic effect of an allele
dependent on which alleles are present at other loci. Two new genomic studies find …

Epistasis is the dependency of the effect of a mutation on the genetic background in which it
occurs. Epistasis has been widely documented and implicated in the evolution of species …

Epistasis, or interactions between genes, has long been recognized as fundamentally
important to understanding the structure and function of genetic pathways and the …

Whether systematic genetic interactions (epistasis) occur at the genomic scale remains a
challenging topic in evolutionary biology. Epistasis should make a significant contribution to …

Intragenic interactions in which the effects of one gene or set of genes influence the effects
of another are referred to as epistasis. This phenomenon is of particular relevance to the …