Background: The expression of human complement regulators has been proved as an
effective strategy to overcome hyperacute rejection in discordant xenogeneic organ …

We characterize a line of transgenic pigs that express the human complement-regulatory
proteins human CD59 and human decay-accelerating factor. These genes, under the control …

Organs of transgenic pigs that express human complement regulatory proteins are under
assessment as an alternative to transplantation. A major barrier to the transplantation of pig …

We have previously created transgenic pigs bearing the human complement regulatory
proteins CD59 and decay‐accelerating factor (DAF) by either the intercellular transfer or the …

New transgenic pigs expressing combinations of regulators of complement activation and
other molecules are needed to resist xenograft hyperacute rejection (HAR) and to further …

We established several swine endothelial cell (SEC) lines, expressing human MCP (CD46),
DAF (CD55), and MCP/DAF hybrid by transfection of cDNA, and assessed the function of …

Since complement-mediated hyperacute rejection of xenografts prevents the use of pigs as
organ donors to man, the development of transgenic animals expressing species-specific …

Background. It has been proposed that hyperacute rejection (HAR) of pig-to-primate
vascularized xenografts is due in large part to ineffective regulation of recipient complement …

The serious shortage of human organs available for transplantation has engendered a
heightened interest in the use of animal organs (xenografts) for transplantation. However …

The critical shortage of human donor organs has generated growing interest for porcine to
human xenotransplantation. The major immunological barrier to xenotransplantation is the …