The sinus node is a collection of highly specialised cells constituting the heart's pacemaker.
The molecular underpinnings of its pacemaking abilities are debated. Using high-resolution …

Rationale: Treatment of sinus node disease with regenerative or cell-based therapies will
require a detailed understanding of gene regulatory networks in cardiac pacemaker cells …

Even before the sinoatrial node (SAN) was discovered, cardiovascular science was
engaged in an active investigation of when and why the heart would beat. After the …

Bioelectrical impulses intrinsically generated within the sinoatrial node (SAN) trigger the
contraction of the heart in mammals. Though discovered over a century ago, the molecular …

Background—Although we know much about the molecular makeup of the sinus node (SN)
in small mammals, little is known about it in humans. The aims of the present study were to …

Ion channels on the surface membrane of sinoatrial nodal pacemaker cells (SANCs) are the
proximal cause of an action potential. Each individual channel type has been thoroughly …

Objectives This study sought to investigate the shift of leading pacemaker locations in
healthy and failing mammalian hearts over the entire range of physiological heart rates …

The spontaneous rhythmic action potentials generated by the sinoatrial node (SAN), the
primary pacemaker in the heart, dictate the regular and optimal cardiac contractions that …

Rationale: Cardiac pacemaker cells (PCs) in the sinoatrial node (SAN) have a distinct gene
expression program that allows them to fire automatically and initiate the heartbeat …

The sinoatrial node is the primary pacemaker of the heart. Nodal dysfunction with aging,
heart failure, atrial fibrillation, and even endurance athletic training can lead to a wide variety …