Enhanced glycolysis and accumulation of lactate is a common feature in various types of
cancer. Intracellular lactate drives a recently described type of posttranslational modification …

The Warburg effect, one of the hallmarks of tumors, produces large amounts of lactate and
generates an acidic tumor microenvironment via using glucose for glycolysis. As a …

Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with
cell metabolism that represents a novel epigenetic code affecting the fate of cells including …

Cancer cells tend to utilize aerobic glycolysis to generate energy and metabolites; the end
product of aerobic glycolysis is lactate, which promotes lysine lactylation (Kla). Kla is a newly …

Lactate is not only an endpoint of glycolysis but is gradually being discovered to play the
role of a universal metabolic fuel for energy via the 'lactate shuttle'moving between cells and …

Lactate is a glycolytic product and a significant energy source. Moreover, it regulates gene
transcription via lactylation of histones and non-histone proteins, ie, a novel posttranslational …

Lactate is an abundant oncometabolite in the tumor environment. In prostate cancer, cancer-
associated fibroblasts (CAF) are major contributors of secreted lactate, which can be taken …

Lactate accumulates to a significant amount in glioblastomas (GBMs), the most common
primary malignant brain tumor with an unfavorable prognosis. However, it remains unclear …

Immune evasion and metabolic reprogramming are two fundamental hallmarks of cancer.
Interestingly, lactate closely links them together. However, lactate has long been recognized …

The Warburg effect, which originally described increased production of lactate in cancer, is
associated with diverse cellular processes such as angiogenesis, hypoxia, polarization of …