The cellular response to changes in the surrounding environment and to stress requires the
coregulation of gene networks aiming to conserve energy and resources. This is often …

Cells encountering hostile growth conditions, like those residing in the middle of a newly
developing solid tumor, conserve resources and energy by downregulating protein …

Upon cell-cycle arrest or nutrient deprivation, the cellular rate of ribosome production is
reduced significantly. In mammalian cells, this effect is achieved in part through a co …

The synthesis of many mammalian proteins associated with the translational apparatus is
selectively regulated by mitogenic and nutritional stimuli, at the translational level. The …

Vertebrate TOP mRNAs contain an oligopyrimidine tract at their 5′ termini (5′ TOP) and
encode components of the translational machinery. Previously it has been shown that they …

Cells encountering hypoxic stress conserve resources and energy by downregulating the
protein synthesis. Here we demonstrate that one mechanism in this response is the …

The response of cells to changes in their environment often requires coregulation of gene
networks, but little is known about how this can occur at the post-transcriptional level. An …

Translation of terminal oligopyrimidine tract (TOP) mRNAs, which encode multiple
components of the protein synthesis machinery, is known to be controlled by mitogenic …

TOP mRNAs are vertebrate transcripts which contain a 5′ terminal oligopyrimidine tract
(5′ TOP), encode for ribosomal proteins and elongation factors 1α and 2, and are …

LARP1 is a key repressor of TOP mRNA translation. It binds the m7Gppp cap moiety and the
adjacent 5′ TOP motif of TOP mRNAs, thus impeding the assembly of the eIF4F complex …