DNA replication is a fundamental process of the cell that ensures accurate duplication of the
genetic information and subsequent transfer to daughter cells. Various pertubations …

To ensure the fidelity of DNA replication, cells activate a stress-response pathway when
DNA replication is perturbed. This pathway regulates not only progress through the cell …

Faithful DNA replication is critical for the maintenance of genomic integrity. Although DNA
replication machinery is highly accurate, the process of DNA replication is constantly …

The replication-stress response enables the DNA replication machinery to overcome DNA
lesions or intrinsic replication-fork obstacles, and it is essential to ensure faithful …

Precise replication of genetic material is essential to maintain genome stability. DNA
replication is a tightly regulated process that ensues faithful copies of DNA molecules to …

The genome of proliferating cells must be precisely duplicated in each cell division cycle.
Chromosomal replication entails risks such as the possibility of introducing breaks and/or …

Complete and accurate DNA replication is essential to genome stability maintenance during
cellular division. However, cells are routinely challenged by endogenous as well as …

DNA replication must be tightly regulated to ensure that the genome is accurately duplicated
during each cell cycle. When these regulatory mechanisms fail, replicative stress and DNA …

Alterations of the dynamics of DNA replication cause genome instability. These alterations
known as “replication stress” have emerged as a major source of genomic instability in pre …

The interplay between replication stress and the S phase checkpoint is a key determinant of
genome maintenance, and has a major impact on human diseases, notably, tumour …