A phase 1, randomized, placebo-controlled study to evaluate the safety and immunogenicity of an mRNA-based RSV prefusion F protein vaccine in healthy younger …

AO Aliprantis, CA Shaw, P Griffin… - Human vaccines & …, 2021 - Taylor & Francis
ABSTRACT Respiratory Syncytial Virus (RSV) causes lower respiratory tract infections that
can be severe and sometimes fatal. The risk for severe RSV infection is highest in infants …

[HTML][HTML] Efficacy and safety of an mRNA-based RSV PreF vaccine in older adults

E Wilson, J Goswami, AH Baqui… - … England Journal of …, 2023 - Mass Medical Soc
Background Respiratory syncytial virus (RSV) can cause substantial morbidity and mortality
among older adults. An mRNA-based RSV vaccine, mRNA-1345, encoding the stabilized …

Efficacy and safety of a bivalent RSV prefusion F vaccine in older adults

EE Walsh, G Pérez Marc, AM Zareba… - … England Journal of …, 2023 - Mass Medical Soc
Background Respiratory syncytial virus (RSV) infection causes considerable illness in older
adults. The efficacy and safety of an investigational bivalent RSV prefusion F protein–based …

Safety and immunogenicity of a respiratory syncytial virus prefusion F (RSVPreF3) candidate vaccine in older adults: phase 1/2 randomized clinical trial

I Leroux-Roels, MG Davis, K Steenackers… - The Journal of …, 2023 - academic.oup.com
Background The aim of this study was to investigate safety and immunogenicity of vaccine
formulations against respiratory syncytial virus (RSV) containing the stabilized prefusion …

[HTML][HTML] Respiratory syncytial virus prefusion F protein vaccine in older adults

A Papi, MG Ison, JM Langley, DG Lee… - … England Journal of …, 2023 - Mass Medical Soc
Background Respiratory syncytial virus (RSV) is an important cause of acute respiratory
infection, lower respiratory tract disease, clinical complications, and death in older adults …

An adjuvanted, postfusion F protein–based vaccine did not prevent respiratory syncytial virus illness in older adults

J Falloon, J Yu, MT Esser, T Villafana… - The Journal of …, 2017 - academic.oup.com
Background Respiratory syncytial virus (RSV) is an important cause of illness in older adults.
This study assessed efficacy of a vaccine for prevention of RSV-associated acute respiratory …

Vaccine efficacy in adults in a respiratory syncytial virus challenge study

B Schmoele-Thoma, AM Zareba, Q Jiang… - … England Journal of …, 2022 - Mass Medical Soc
Background Although human respiratory syncytial virus (RSV) is an important cause of
illness and death in older adults, no RSV vaccine has been licensed. Methods In a phase 2a …

Respiratory syncytial virus: targeting the G protein provides a new approach for an old problem

RA Tripp, UF Power, PJM Openshaw… - Journal of virology, 2018 - Am Soc Microbiol
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection (LRTI)
annually affecting> 2 million children in the United States< 5 years old. In the elderly (> 65 …

Immunogenicity and safety of a respiratory syncytial virus fusion protein (RSV F) nanoparticle vaccine in older adults

L Fries, V Shinde, JJ Stoddard, DN Thomas… - Immunity & …, 2017 - Springer
Background A preventative strategy for Respiratory Syncytial Virus (RSV) infection
constitutes an under-recognized unmet medical need among older adults. Four formulations …

Respiratory syncytial virus prefusion F protein vaccine is efficacious in older adults with underlying medical conditions

RG Feldman, R Antonelli-Incalzi… - Clinical Infectious …, 2024 - academic.oup.com
Background Older adults with chronic cardiorespiratory or endocrine/metabolic conditions
are at increased risk of respiratory syncytial virus (RSV)-related acute respiratory illness …