Caloric restriction (CR) is argued to positively affect general health, longevity and the
normally occurring age-related reduction of cognition. This issue is well examined, but most …

Caloric restriction (CR) is effective in slowing aging and delaying aging-related diseases in
many species, but the mechanism is complex and not fully elucidated. This study aimed to …

Little is known about the mechanisms by which acute and chronic caloric restriction (CR)
modulate disease, longevity, and toxicity. To study these endpoints, behavioral parameters …

Controversy exists as to whether lifelong 40% calorie restriction (CR) enhances, has no
effect on, or disrupts cognitive function during aging. Here, we report the effects of CR versus …

Fourteen-month-old C57BL/6 (NIA) mice were placed on a nutritionally complete diet
providing 139.4 kcal/week. Over a 2-month period the food ration of experimental mice (AE) …

Caloric restriction (CR) is an effective method for prevention of age-associated diseases as
well as overweight and obesity; however, there is controversy regarding the effects of dieting …

Although the beneficial effects of diet restriction on longevity and the retardation of many
somatic age-related processes are well established, the answer to the question of whether …

Background In rodent models, caloric restriction (CR) with maintenance of adequate
micronutrient supply has been reported to increase lifespan and to reduce age‐induced …

Caloric restriction (CR) increases maximum life span in many species. In laboratory rodents,
it opposes the development of age-associated biological and pathological changes …

Caloric restriction (CR) extends lifespan in mammals, yet the mechanisms underlying its
beneficial effects remain unknown. The manner in which CR has been implemented in …