The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

Old age is associated with a large spectrum of physical ailments, including muscle wasting.
Skeletal muscle degeneration drastically increases the risk of poor balance, frequent falling …

Extended longevity is often accompanied by frailty and increased susceptibility to a variety of
crippling disorders. One of the most striking features of human aging is sarcopenia, which is …

Extended human longevity has resulted in increasing numbers of elderly persons in the
general population. However, old age is also associated with a variety of serious physical …

The age-dependent decline in skeletal muscle mass and function is believed to be due to a
multi-factorial pathology and represents a major factor that blocks healthy aging by …

Key points Loss of muscle mass and strength in the growing population of elderly people is
a major health concern for modern societies. This condition, termed sarcopenia, is a major …

A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty
in older persons, but the molecular mechanisms of such decline are not understood. Here …

Skeletal muscle is a key tissue in human aging, which affects different muscle fiber types
unequally. We developed a highly sensitive single muscle fiber proteomics workflow to study …

Aging is associated with a progressive decline of muscle mass, strength, and quality, a
condition described as sarcopenia of aging. Despite the significance of skeletal muscle …

This review focuses on the role of changes in the contractile proteins actin and myosin in
age-related deterioration of skeletal muscle function. Functional and structural changes in …