In early 1920s, tyramine oxidase was discovered that metabolized tyramine and in 1933
Blaschko demonstrated that this enzyme also metabolized adrenaline, noradrenaline and …

A few years after the foundation of the British Pharmacological Society, monoamine oxidase
(MAO) was recognized as an enzyme of crucial interest to pharmacologists because it …

Abstract Monoamine oxidase (MAO; EC 1.4: 3.4; amine: oxygen oxidoreductase;
deaminating; flavine-containing) is an enzyme that oxidizes a variety of monoamine …

Iron has been shown to accumulates at site where neurons degenerate in
neurodegenerative diseases of Parkinson's disease, Alzheimer's disease, Huntington …

In the absence of identification of either an endogenously or an exogenously derived
dopaminergic neurotoxin, the most valid hypothesis currently envisaged for etiopathology of …

Iron‐dependent oxidative stress, elevated levels of iron and of monoamine oxidase (MAO)‐
B activity, and depletion of antioxidants in the brain may be major pathogenic factors in …

The enzyme monoamine oxidase (MAO) was described by multiple investigators in the
1920s and 1930s, carrying such names as “tyramine oxidase,""“adrenaline oxidase,” and …

Inhibitors of MAO-A and MAO-B are in clinical use for the treatment of psychiatric and
neurological disorders respectively. Elucidation of the molecular structure of the active sites …

Several multifunctional iron chelators have been synthesized from hydroxyquinoline
pharmacophore of the iron chelator, VK‐28, possessing the monoamine oxidase (MAO) and …

This article outlines the latest information on the clinical efficacy of MAOIs and provides the
physician with guidelines for their safe use. The important side effects of this class of drugs …