Parkinson's disease is the second most common neurodegenerative disease. Unfortunately,
there is still no definitive disease-modifying therapy. In our work, the antiparkinsonian …

Background The present study was intended to investigate the protective effect of estradiol
against Parkinson's disease through the use of rotenone-induced neurotoxicity model …

Oleracein E (OE), a tetrahydroisoquinoline possessing potent antioxidant activity, was first
isolated from a traditional Chinese medicine, Portulaca oleraea L., and is hypothesized to be …

Major pathological features of Parkinson's disease (PD) include increase in oxidative stress
leading to the aggregation of α-synuclein, mitochondrial dysfunction and apoptosis of …

Oxidative stress is considered one of the mechanisms responsible for neurodegenerative
diseases, especially for Parkinson's disease. Since oxidative stress causes pathological …

Parkinson's disease (PD) is a progressive neurodegenerative disorder, primarily affecting
dopaminergic neurons in the substantia nigra. There is currently no cure for PD and present …

Dysfunction of autophagy, mitochondrial dynamics and endoplasmic reticulum (ER) stress
are currently considered as major contributing factors in the pathogenesis of Parkinson's …

Phloretin and phlorizin are the two strong natural antioxidants whose biological and
pharmacological applications are rapidly growing in different human pathological …

Parkinson's disease (PD) is a common, chronic, and debilitating neurodegenerative disorder
characterized by progressive loss of nigrostriatal dopaminergic neurons due to unknown …

Oxidative stress and mitochondrial dysfunction are two pathophysiological factors often
associated with the neurodegenerative process involved in Parkinson's disease (PD). The …