Several cardiac and renal diseases are attributed to a dysregulation of the renin-angiotensin
system. Renin, the rate-limiting enzyme of the renin-angiotensin system, has 2 isoforms. The …

The renin–angiotensin system (RAS) in the brain is a critical determinant of blood pressure,
but the mechanisms regulating RAS activity in the brain remain unclear. Expression of brain …

Renin plays a key role in controlling blood pressure through its specific cleavage of
angiotensinogen to generate angiotensin I (AI). Although possible existence of the other …

The renin-angiotensin system plays an important role in the control of blood pressure (BP)
and renal function. To illuminate the importance of renin in the context of a disease …

The brain-specific isoform of renin (Ren-b) has been proposed as a negative regulator of the
brain renin–angiotensin system (RAS). We analyzed mice with a selective deletion of Ren-b …

Because of the presence of the blood–brain barrier, brain renin–angiotensin system activity
should depend on local (pro) renin synthesis. Indeed, an intracellular form of renin has been …

The brain renin–angiotensin system is implicated in the regulation of blood pressure (BP)
and fluid homeostasis. Recent studies reveal that 2 forms of renin are expressed in the brain …

Background The renin–angiotensin–aldosterone system (RAAS) plays pivotal roles in the
pathogenesis of chronic kidney disease (CKD) progression. Aliskiren, a direct renin inhibitor …

The renin-angiotensin system is known to regulate blood pressure as well as water-and
electrolyte balance. An activated RAS is involved in the development of hypertension and …

Renal artery stenosis is a common condition in patients with coronary or peripheral vascular
disease where the renin angiotensin aldosterone system (RAAS) is overactivated. In this …