Omics sciences for systems biology in Alzheimer's disease: State-of-the-art of the evidence
Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …
Revolution of Alzheimer precision neurology. Passageway of systems biology and neurophysiology
The Precision Neurology development process implements systems theory with system
biology and neurophysiology in a parallel, bidirectional research path: a combined …
biology and neurophysiology in a parallel, bidirectional research path: a combined …
Integrative neurobiology of metabolic diseases, neuroinflammation, and neurodegeneration
G van Dijk, S van Heijningen, AC Reijne… - Frontiers in …, 2015 - frontiersin.org
Alzheimer's disease (AD) is a complex, multifactorial disease with a number of leading
mechanisms, including neuroinflammation, processing of amyloid precursor protein (APP) to …
mechanisms, including neuroinflammation, processing of amyloid precursor protein (APP) to …
Deciphering complex mechanisms in neurodegenerative diseases: the advent of systems biology
Classical biological methods involving analyses of one or several genes have been the
mainstay for studying the pathogenesis of neurodegenerative disorders. However, it has …
mainstay for studying the pathogenesis of neurodegenerative disorders. However, it has …
Precision pharmacology for Alzheimer's disease
The complex multifactorial nature of polygenic Alzheimer's disease (AD) presents significant
challenges for drug development. AD pathophysiology is progressing in a non-linear …
challenges for drug development. AD pathophysiology is progressing in a non-linear …
Alzheimer's disease in the omics era
GM Sancesario, S Bernardini - Clinical biochemistry, 2018 - Elsevier
Recent progresses in high-throughput technologies have led to a new scenario in
investigating pathologies, named the “Omics era”, which integrate the opportunity to collect …
investigating pathologies, named the “Omics era”, which integrate the opportunity to collect …
Development of biomarkers to chart all Alzheimer's disease stages: the royal road to cutting the therapeutic Gordian Knot
The aim of this perspective article is to stimulate radical shifts in thinking and foster further
discussion on the effective discovery, development, validation, and qualification process of …
discussion on the effective discovery, development, validation, and qualification process of …
Dissecting complex and multifactorial nature of Alzheimer's disease pathogenesis: a clinical, genomic, and systems biology perspective
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by loss
of memory and other cognitive functions. AD can be classified into familial AD (FAD) and …
of memory and other cognitive functions. AD can be classified into familial AD (FAD) and …
A multiomics approach to heterogeneity in Alzheimer's disease: focused review and roadmap
Aetiological and clinical heterogeneity is increasingly recognized as a common
characteristic of Alzheimer's disease and related dementias. This heterogeneity complicates …
characteristic of Alzheimer's disease and related dementias. This heterogeneity complicates …
The future of precision medicine in the cure of Alzheimer's disease
This decade has seen the beginning of ground-breaking conceptual shifts in the research of
Alzheimer's disease (AD), which acknowledges risk elements and the evolving wide …
Alzheimer's disease (AD), which acknowledges risk elements and the evolving wide …