Ceramide (Cer) is a bioactive cellular lipid with compartmentalized and tightly regulated
levels. Distinct metabolic pathways lead to the generation of Cer species with …

Abstract Fenretinide, N-(4-hydroxyphenyl) retinamide,(4-HPR), a synthetic retinoid, owes its
cancer-toxic effects in part to the generation of ceramide, a potent tumor-suppressing …

We previously reported that fenretinide (4-HPR) was cytotoxic to acute lymphoblastic
leukemia (ALL) cell lines in vitro in association with increased levels of de novo synthesized …

Treatment with the synthetic retinoid HPR [N-(4-hydroxyphenyl)-retinamide] causes growth
arrest and apoptosis in HTLV-I (human T-cell lymphotropic virus type-I)-positive and HTLV-I …

Abstract 1257 Drug resistance to chemotherapy is a major obstacle to the treatment of
primarily refractory and relapsed pediatric acute lymphoblastic leukemias (ALL). The …

Increased generation of dihydrosphingosine (DHS), a bioactive sphingolipid, has been
implicated in the cytotoxicity of the synthetic retinoid N-(4-hydroxyphenyl) retinamide (4 …

Ceramide metabolism has emerged as a potential target for anticancer therapy. Here, the
potential usefulness of two novel synthetic ceramide analogs as anti-leukemic drugs was …

4-(Hydroxyphenyl) retinamide (4-HPR) is a synthetic retinoid with a strong apoptotic effect
towards different cancer cell lines in vitro, and it is currently tested in clinical trials. Increases …

Ceramide (Cer) accumulating during the execution phase of apoptosis is generated from
plasma membrane sphingomyelin (SM), which gains access to a sphingomyelinase due to …

Background Leukaemia cells differ from their normal counterparts in that their ability to
properly regulate survival, proliferation, differentiation, and apoptosis is aberrant …