Aims: The pathophysiological role of iron in Parkinson's disease (PD) was assessed by a
chelation strategy aimed at reducing oxidative damage associated with regional iron …

Parkinson's disease (PD) is associated with increased iron levels in the substantia nigra
(SNc). This study evaluated whether the iron chelator, deferiprone, is well tolerated, able to …

A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …

Iron is an essential element in the metabolism of all cells. Elevated levels of the metal have
been found in the brains of patients of numerous neurodegenerative disorders, including …

Focal iron accumulation associated with brain iron dyshomeostasis is a pathological
hallmark of various neurodegenerative diseases (NDD). The application of iron-sensitive …

Brain iron accumulation has been implicated in a host of chronic neurological diseases,
including Parkinson's disease (PD). The elevated iron levels observed in the substantia …

Mitochondrial dysfunction, iron accumulation, and oxidative damage are conditions often
found in damaged brain areas of Parkinson's disease. We propose that a causal link exists …

Dysfunction of iron metabolism, which includes its uptake, storage, and release, plays a key
role in neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer's …

Although the aetiology of Parkinson's disease (PD) and related neurodegenerative
disorders is still unknown, recent evidence from human and experimental animal models …

Iron accumulation is a cardinal feature of degenerating regions in the Parkinson's disease
brain. As a potent pro-oxidant, redox-active iron may be a key player in upstream …