Fibroblast activation protein inhibitor tracers and their preclinical, translational, and clinical status in China
Quinoline-based fibroblast activation protein (FAP) inhibitors (FAPIs) have recently emerged
as a focal point in global nuclear medicine, underscored by their promising applications in …
as a focal point in global nuclear medicine, underscored by their promising applications in …
Clinical summary of fibroblast activation protein inhibitor-based radiopharmaceuticals: cancer and beyond
Fibroblast activation protein (FAP) is a type II membrane-bound glycoprotein which is
overexpressed in cancer-associated fibroblasts and activated fibroblasts at wound …
overexpressed in cancer-associated fibroblasts and activated fibroblasts at wound …
[HTML][HTML] Fibroblast activation protein-based theranostics in cancer research: a state-of-the-art review
In recent years, quinoline-based fibroblast activation protein (FAP) inhibitors (FAPI) have
shown promising results in the diagnosis of cancer and several other diseases, making them …
shown promising results in the diagnosis of cancer and several other diseases, making them …
68Ga-FAPI PET/CT: tracer uptake in 28 different kinds of cancer
C Kratochwil, P Flechsig, T Lindner… - Journal of Nuclear …, 2019 - Soc Nuclear Med
The recent development of quinoline-based PET tracers that act as fibroblast-activation-
protein inhibitors (FAPIs) demonstrated promising preclinical and clinical results. FAP is …
protein inhibitors (FAPIs) demonstrated promising preclinical and clinical results. FAP is …
Clinical applications of fibroblast activation protein‐targeted theranostics in oncologic and nononcologic disease: Current status and future directions
H Fu, W Guo, J Huang, H Wu, H Chen - iRADIOLOGY, 2023 - Wiley Online Library
Quinoline‐based fibroblast activation protein (FAP) inhibitor (FAPI)‐based positron emission
tomography (PET) imaging and radioligand therapy (RLT) are being investigated for use in a …
tomography (PET) imaging and radioligand therapy (RLT) are being investigated for use in a …
[HTML][HTML] FAPI-avid nonmalignant PET/CT findings: an expedited systematic review
M Bentestuen, N Al-Obaydi, HD Zacho - Seminars in Nuclear Medicine, 2023 - Elsevier
Fibroblast activation protein inhibitor (FAPI) is a promising tracer in oncologic positron
emission tomography/computed tomography (PET/CT). Numerous studies have …
emission tomography/computed tomography (PET/CT). Numerous studies have …
Fibroblast activation protein inhibitor imaging in nonmalignant diseases: a new perspective for molecular imaging
C Schmidkonz, T Kuwert, A Atzinger… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Fibroblast activation protein-α (FAP-α) is a type II transmembrane glycoprotein that is
overexpressed in activated fibroblasts such as those in the stroma of tumors or in the fibrotic …
overexpressed in activated fibroblasts such as those in the stroma of tumors or in the fibrotic …
68Ga-FAPI PET/CT: biodistribution and preliminary dosimetry estimate of 2 DOTA-containing FAP-targeting agents in patients with various cancers
FL Giesel, C Kratochwil, T Lindner… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts of
several tumor entities. The recent development of quinoline-based PET tracers that act as …
several tumor entities. The recent development of quinoline-based PET tracers that act as …
Radiation dosimetry and biodistribution of 68Ga-FAPI-46 PET imaging in cancer patients
Targeting cancer-associated fibroblasts (CAFs) has become an attractive goal for diagnostic
imaging and therapy because they can constitute as much as 90% of a tumor mass. The …
imaging and therapy because they can constitute as much as 90% of a tumor mass. The …
[HTML][HTML] 99mTc-labeled FAPI compounds for cancer and inflammation: from radiochemistry to the first clinical applications
A Boschi, L Urso, L Uccelli, P Martini… - EJNMMI Radiopharmacy …, 2024 - Springer
Background In recent years, fibroblast activating protein (FAP), a biomarker overexpressed
by cancer-associated fibroblasts, has emerged as one of the most promising biomarkers in …
by cancer-associated fibroblasts, has emerged as one of the most promising biomarkers in …