Deep in vivo photoacoustic imaging of mammalian tissues using a tyrosinase-based genetic reporter

AP Jathoul, J Laufer, O Ogunlade, B Treeby, B Cox… - Nature …, 2015 - nature.com
Photoacoustic imaging allows absorption-based high-resolution spectroscopic in vivo
imaging at a depth beyond that of optical microscopy. Until recently, photoacoustic imaging …

Photoacoustic imaging using genetically encoded reporters: a review

J Brunker, J Yao, J Laufer… - Journal of biomedical …, 2017 - spiedigitallibrary.org
Genetically encoded contrast in photoacoustic imaging (PAI) is complementary to the
intrinsic contrast provided by endogenous absorbing chromophores such as hemoglobin …

Multicontrast photoacoustic in vivo imaging using near-infrared fluorescent proteins

A Krumholz, DM Shcherbakova, J Xia, LV Wang… - Scientific reports, 2014 - nature.com
Non-invasive imaging of biological processes in vivo is invaluable in advancing biology.
Photoacoustic tomography is a scalable imaging technique that provides higher resolution …

Photoacoustic microscopy of tyrosinase reporter gene in vivo

A Krumholz, SJ VanVickle-Chavez… - … of biomedical optics, 2011 - spiedigitallibrary.org
Photoacoustic tomography is a hybrid modality based on optical absorption excitation and
ultrasonic detection. It is sensitive to melanin, one of the primary absorbers in skin. For cells …

A practical guide to photoacoustic tomography in the life sciences

LV Wang, J Yao - Nature methods, 2016 - nature.com
The life sciences can benefit greatly from imaging technologies that connect microscopic
discoveries with macroscopic observations. One technology uniquely positioned to provide …

Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging

HF Zhang, K Maslov, G Stoica, LV Wang - Nature biotechnology, 2006 - nature.com
Although optical absorption is strongly associated with the physiological status of biological
tissue, existing high-resolution optical imaging modalities, including confocal microscopy …

Photoacoustic imaging of lacZ gene expression in vivo

L Li, RJ Zemp, G Lungu, G Stoica… - Journal of biomedical …, 2007 - spiedigitallibrary.org
In the postgenomic era, imaging techniques are playing an important role in visualizing
gene expression in vivo. This work represents the first demonstration of photoacoustic …

Functional photoacoustic imaging: from nano-and micro-to macro-scale

B Park, D Oh, J Kim, C Kim - Nano Convergence, 2023 - Springer
Functional photoacoustic imaging is a promising biological imaging technique that offers
such unique benefits as scalable resolution and imaging depth, as well as the ability to …

Photoacoustic tomography: in vivo imaging from organelles to organs

LV Wang, S Hu - science, 2012 - science.org
Photoacoustic tomography (PAT) can create multiscale multicontrast images of living
biological structures ranging from organelles to organs. This emerging technology …

Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system

C Kim, TN Erpelding, L Jankovic… - Biomedical optics …, 2010 - opg.optica.org
Using a hand-held photoacoustic probe integrated with a clinical ultrasound array system,
we successfully imaged objects deeply positioned in biological tissues. The optical contrasts …