Efficient production of glucaric acid by engineered Saccharomyces cerevisiae

Y Zhao, F Zuo, Q Shu, X Yang… - Applied and …, 2023 - Am Soc Microbiol
Glucaric acid is a valuable chemical with applications in the detergent, polymer,
pharmaceutical and food industries. In this study, two key enzymes for glucaric acid …

Metabolic engineering of Saccharomyces cerevisiae for efficient production of glucaric acid at high titer

N Chen, J Wang, Y Zhao, Y Deng - Microbial cell factories, 2018 - Springer
Background Glucaric acid is a high-value-added chemical that can be used in various fields.
Because chemical oxidation of glucose to produce glucaric acid is not environmentally …

Consolidated bioprocessing of lignocellulose for production of glucaric acid by an artificial microbial consortium

C Li, X Lin, X Ling, S Li, H Fang - Biotechnology for Biofuels, 2021 - Springer
Background The biomanufacturing of d-glucaric acid has attracted increasing interest
because it is one of the top value-added chemicals produced from biomass. Saccharomyces …

Effect of magnesium ions on glucaric acid production in the engineered Saccharomyces cerevisiae

Y Zhao, J Li, R Su, Y Liu, J Wang, Y Deng - Journal of Biotechnology, 2021 - Elsevier
Glucaric acid has been successfully produced in Escherichia coli and fungus. Here, we first
analyzed the effects of different metal ions on glucaric acid production in the engineered …

Porting the synthetic D‐glucaric acid pathway from Escherichia coli to Saccharomyces cerevisiae

A Gupta, MA Hicks, SP Manchester… - Biotechnology …, 2016 - Wiley Online Library
D‐Glucaric acid can be produced as a value‐added chemical from biomass through a de
novo pathway in Escherichia coli. However, previous studies have identified pH‐mediated …

Production of glucaric acid from myo-inositol in engineered Pichia pastoris

Y Liu, X Gong, C Wang, G Du, J Chen… - Enzyme and microbial …, 2016 - Elsevier
A potential myo-inositol oxygenase (ppMIOX) was identified as a functional enzyme and a
glucaric acid synthetic pathway was firstly constructed in Pichia pastoris. Coexpression of …

Production of d-glucaric acid with phosphoglucose isomerase-deficient Saccharomyces cerevisiae

M Toivari, ML Vehkomäki, L Ruohonen, M Penttilä… - Biotechnology …, 2024 - Springer
Abstract d-Glucaric acid is a potential biobased platform chemical. Previously mainly
Escherichia coli, but also the yeast Saccharomyces cerevisiae, and Pichia pastoris, have …

Efficient production of glycyrrhetinic acid in metabolically engineered Saccharomyces cerevisiae via an integrated strategy

C Wang, X Su, M Sun, M Zhang, J Wu, J Xing… - Microbial Cell …, 2019 - Springer
Background Glycyrrhetinic acid (GA) is the most important ingredient in licorice due to its
outstanding anti-inflammatory activity and wide application in the medicine and cosmetics …

[HTML][HTML] Metabolic Engineering for Glycyrrhetinic Acid Production in Saccharomyces cerevisiae

R Guan, M Wang, Z Guan, CY Jin, W Lin… - … in Bioengineering and …, 2020 - frontiersin.org
Glycyrrhetinic acid (GA) is one of the main bioactive components of licorice, and it is widely
used in traditional Chinese medicine due to its hepatoprotective, immunomodulatory, anti …

Enhancing glucaric acid production from myo-inositol in Escherichia coli by eliminating cell-to-cell variation

N Ding, L Sun, X Zhou, L Zhang… - Applied and …, 2024 - Am Soc Microbiol
Glucaric acid (GA) is a value-added chemical and can be used to manufacture food
additives, anticancer drugs, and polymers. The non-genetic cell-to-cell variations in GA …