[HTML][HTML] Mechanism of sorafenib resistance associated with ferroptosis in HCC
L Guo, C Hu, M Yao, G Han - Frontiers in pharmacology, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) is the most familiar primary hepatic malignancy with a poor
prognosis. The incidence of HCC and the associated deaths have risen in recent decades …
prognosis. The incidence of HCC and the associated deaths have risen in recent decades …
[HTML][HTML] From synergy to resistance: Navigating the complex relationship between sorafenib and ferroptosis in hepatocellular carcinoma
Z Wang, C Zhou, Y Zhang, X Tian, H Wang, J Wu… - Biomedicine & …, 2024 - Elsevier
Hepatocellular carcinoma (HCC) remains a major global health burden, and sorafenib, a
multi-kinase inhibitor, has shown effectiveness in the treatment of HCC and is considered as …
multi-kinase inhibitor, has shown effectiveness in the treatment of HCC and is considered as …
Role of ferroptosis in hepatocellular carcinoma
J Nie, B Lin, M Zhou, L Wu, T Zheng - Journal of cancer research and …, 2018 - Springer
Purpose Hepatocellular carcinoma (HCC) is a complicated disease with low survival rate
due to frequent recurrence and the lack of efficient therapies. For advanced HCC, sorafenib …
due to frequent recurrence and the lack of efficient therapies. For advanced HCC, sorafenib …
Iron‐dependent cell death of hepatocellular carcinoma cells exposed to sorafenib
C Louandre, Z Ezzoukhry, C Godin… - … journal of cancer, 2013 - Wiley Online Library
The multikinase inhibitor sorafenib is currently the treatment of reference for advanced
hepatocellular carcinoma (HCC). In our report, we examined the cytotoxic effects of …
hepatocellular carcinoma (HCC). In our report, we examined the cytotoxic effects of …
Understanding sorafenib-induced ferroptosis and resistance mechanisms: implications for cancer therapy
Q Li, K Chen, T Zhang, D Jiang, L Chen, J Jiang… - European Journal of …, 2023 - Elsevier
Sorafenib is an important first-line treatment option for liver cancer due to its well-
characterized safety profile. While novel first-line drugs may have better efficacy than …
characterized safety profile. While novel first-line drugs may have better efficacy than …
[HTML][HTML] Iron deficiency in hepatocellular carcinoma cells induced sorafenib resistance by upregulating HIF-1α to inhibit apoptosis
Z Gao, D Wang, J Yang, M Li, C Ling, D Lv… - Biomedicine & …, 2023 - Elsevier
Sorafenib is the first-line therapeutic agent for hepatocellular carcinoma (HCC), but the drug
resistance has become a major impediment. Previously we found that the abnormal iron …
resistance has become a major impediment. Previously we found that the abnormal iron …
[HTML][HTML] The role of ferroptosis in the treatment and drug resistance of hepatocellular carcinoma
S Zhao, W Zheng, C Yu, G Xu, X Zhang… - Frontiers in Cell and …, 2022 - frontiersin.org
Cell death is a fundamental feature of multicellular organisms' development and a key driver
of degenerative diseases. Ferroptosis is a new regulatory cell death mediated by iron …
of degenerative diseases. Ferroptosis is a new regulatory cell death mediated by iron …
Ferroptosis in hepatocellular carcinoma: from bench to bedside
The most widespread type of liver cancer, HCC, is associated with disabled cellular death
pathways. Despite therapeutic advancements, resistance to current systemic treatments …
pathways. Despite therapeutic advancements, resistance to current systemic treatments …
[HTML][HTML] Ferroptosis in hepatocellular carcinoma: mechanisms, drug targets and approaches to clinical translation
Simple Summary In recent decades, scientific discoveries brought up several new
treatments and improvements for patients suffering from hepatocellular carcinoma (HCC) …
treatments and improvements for patients suffering from hepatocellular carcinoma (HCC) …
[HTML][HTML] Camptothecin sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via suppression of Nrf2
Sorafenib is a potent inducer of ferroptosis used to manage hepatocellular carcinoma
(HCC). The ferroptosis induced by sorafenib activates the p62–Keap1–Nrf2 pathway …
(HCC). The ferroptosis induced by sorafenib activates the p62–Keap1–Nrf2 pathway …