Cardiovascular disease is a leading cause of death worldwide and accounts for> 17.3
million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 …

Hypertension is associated with altered structure of the resistance vessels, a process known
as remodeling. This review summarizes current concepts concerning the structure of a …

Hypertension is both a cause and a consequence of central artery stiffening, which in turn is
an initiator and indicator of myriad disease conditions and thus all-cause mortality. Such …

Essential hypertension is characterized by increased peripheral vascular resistance to blood
flow. This resistance results mostly from energy dissipation in small arteries and arterioles …

Vascular remodeling refers to alterations in the structure of resistance vessels contributing to
elevated systemic vascular resistance in hypertension. We start with some historical aspects …

In the present review, microvascular remodelling refers to alterations in the structure of
resistance vessels contributing to elevated systemic vascular resistance in hypertension. We …

Blood vessels are dynamic structures composed of cells and extracellular matrix (ECM),
which are in continuous cross-talk with each other. Thus, cellular changes in phenotype or in …

Diverse data collected over the past 4 decades suggest the existence of a mechanical
homeostasis across multiple length and time scales in the vasculature. For example, 1 stress …

Hypertension is a major risk factor for many common chronic diseases, such as heart failure,
myocardial infarction, stroke, vascular dementia, and chronic kidney disease …

Large conduit arteries and the microcirculation participate in the mechanisms of elevation of
blood pressure (BP). Large vessels play roles predominantly in older subjects, with stiffening …