Shaping of monocyte and macrophage function by adenosine receptors
Adenosine is an endogenous purine nucleoside that, following its release into the
extracellular space, binds to specific adenosine receptors expressed on the cell surface …
extracellular space, binds to specific adenosine receptors expressed on the cell surface …
Adenosine receptors and inflammation
MR Blackburn, CO Vance, E Morschl… - Adenosine receptors in …, 2009 - Springer
Extracellular adenosine is produced in a coordinated manner from cells following cellular
challenge or tissue injury. Once produced, it serves as an autocrine-and paracrine-signaling …
challenge or tissue injury. Once produced, it serves as an autocrine-and paracrine-signaling …
Adenosine, an endogenous anti-inflammatory agent
BN Cronstein - Journal of applied Physiology, 1994 - journals.physiology.org
Adenosine receptors are present on most cells and organs, yet, although the physiological
effects of adenosine were first described over 60 years ago, the potential therapeutic uses of …
effects of adenosine were first described over 60 years ago, the potential therapeutic uses of …
Regulation of neutrophil function by adenosine
Adenosine is an endogenously released purine nucleoside that signals via 4 widely
expressed G protein-coupled receptors: A1, A2A, A2B, and A3. In the setting of inflammation …
expressed G protein-coupled receptors: A1, A2A, A2B, and A3. In the setting of inflammation …
Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection
J Linden - Annual review of pharmacology and toxicology, 2001 - annualreviews.org
Adenosine accumulation during ischemia and inflammation protects tissues from injury. In
ischemic tissues adenosine accumulates due to inhibition of adenosine kinase, and in …
ischemic tissues adenosine accumulates due to inhibition of adenosine kinase, and in …
Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
Adenosine is a key endogenous molecule that regulates tissue function by activating four G-
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …
Regulation of macrophage function by adenosine
Following its release into the extracellular space in response to metabolic disturbances, the
endogenous nucleoside adenosine exerts a range of immunomodulatory effects and cells of …
endogenous nucleoside adenosine exerts a range of immunomodulatory effects and cells of …
Regulation of leukocyte function by adenosine receptors
J Linden - Advances in pharmacology, 2011 - Elsevier
The immune system responds to cues in the microenvironment to make acute and chronic
adaptations in response to inflammation and injury. Locally produced purine nucleotides …
adaptations in response to inflammation and injury. Locally produced purine nucleotides …
cDNA microarray analysis reveals a nuclear factor-κB-independent regulation of macrophage function by adenosine
ZH Néemeth, SJ Leibovich, EA Deitch, ES Vizi… - … of Pharmacology and …, 2003 - ASPET
Adenosine is released into the extracellular space from nerve terminals and cells subjected
to ischemic stress. This nucleoside modulates a plethora of cellular functions via occupancy …
to ischemic stress. This nucleoside modulates a plethora of cellular functions via occupancy …
Adenosine A2a receptors induce heterologous desensitization of chemokine receptors
N Zhang, D Yang, H Dong, Q Chen, DI Dimitrova… - Blood, 2006 - ashpublications.org
Adenosine, released by cells in an injurious or hypoxic environment, possesses potent anti-
inflammatory effects by inhibiting the production of proinflammatory cytokines and …
inflammatory effects by inhibiting the production of proinflammatory cytokines and …