Adenosine is an endogenous purine nucleoside that, following its release into the
extracellular space, binds to specific adenosine receptors expressed on the cell surface …

Extracellular adenosine is produced in a coordinated manner from cells following cellular
challenge or tissue injury. Once produced, it serves as an autocrine-and paracrine-signaling …

Adenosine receptors are present on most cells and organs, yet, although the physiological
effects of adenosine were first described over 60 years ago, the potential therapeutic uses of …

Adenosine is an endogenously released purine nucleoside that signals via 4 widely
expressed G protein-coupled receptors: A1, A2A, A2B, and A3. In the setting of inflammation …

Adenosine accumulation during ischemia and inflammation protects tissues from injury. In
ischemic tissues adenosine accumulates due to inhibition of adenosine kinase, and in …

Adenosine is a key endogenous molecule that regulates tissue function by activating four G-
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …

Following its release into the extracellular space in response to metabolic disturbances, the
endogenous nucleoside adenosine exerts a range of immunomodulatory effects and cells of …

The immune system responds to cues in the microenvironment to make acute and chronic
adaptations in response to inflammation and injury. Locally produced purine nucleotides …

Adenosine is released into the extracellular space from nerve terminals and cells subjected
to ischemic stress. This nucleoside modulates a plethora of cellular functions via occupancy …

Adenosine, released by cells in an injurious or hypoxic environment, possesses potent anti-
inflammatory effects by inhibiting the production of proinflammatory cytokines and …