Urban fine particulate matter exposure causes male reproductive injury through destroying blood-testis barrier (BTB) integrity

X Cao, L Shen, C Yan, Y Zhou, G Xiong, Y Wang, Y Liu… - Toxicology letters, 2017 - Elsevier
Blood-testis barrier (BTB) provides a suitable microenvironment for germ cells that is
required for spermatogenesis. Exposure to particulate matter (PM) is recognized to occasion …

Urban fine particulate matter (PM2. 5) exposure destroys blood–testis barrier (BTB) integrity through excessive ROS-mediated autophagy

Y Wei, XN Cao, XL Tang, LJ Shen, T Lin… - Toxicology …, 2018 - Taylor & Francis
Context: Blood–testis barrier (BTB), constituted by tight junctions (TJs), adherens junctions
and gap junctions, is important for spermatogenesis. PM2. 5 is known to impair testicular …

Automobile exhaust-derived PM2. 5 induces blood-testis barrier damage through ROS-MAPK-Nrf2 pathway in sertoli cells of rats

B Liu, L Shen, T Zhao, M Sun, J Wang, C Long… - Ecotoxicology and …, 2020 - Elsevier
Particulate matter with an aerodynamic diameter of less than 2.5 μm (PM 2.5) derived from
automobile exhaust can lead to serious male spermatogenesis dysfunction, but its specific …

Exposure to Concentrated Ambient PM2.5 Compromises Spermatogenesis in a Mouse Model: Role of Suppression of Hypothalamus-Pituitary-Gonads Axis

L Qiu, M Chen, X Wang, X Qin, S Chen… - Toxicological …, 2018 - academic.oup.com
Epidemiological studies link ambient fine particulate matter (PM2. 5) pollution to
abnormalities in the male reproductive system. However, few toxicological studies have …

The reproductive toxicology of male SD rats after PM2. 5 exposure mediated by the stimulation of endoplasmic reticulum stress

X Liu, X Jin, R Su, Z Li - Chemosphere, 2017 - Elsevier
Evidence has shown that exposure to fine particulate matter (PM) contributed to poor semen
quality in males. However, the reproductive toxicity and relevant molecular mechanisms of …

Fine particulate matter leads to reproductive impairment in male rats by overexpressing phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway

X Cao, C Yan, D Liu, J Peng, J Chen, Y Zhou, C Long… - Toxicology letters, 2015 - Elsevier
Maintenance of male reproductive function depends on normal sperm generation during
which process Sertoli cells play a vital role. Studies found that fine particulate matter (PM) …

Fine particle matter disrupts the blood–testis barrier by activating TGF‐β3/p38 MAPK pathway and decreasing testosterone secretion in rat

J Liu, L Ren, J Wei, J Zhang, Y Zhu, X Li… - Environmental …, 2018 - Wiley Online Library
Fine particle matter (PM) is correlated with male reproductive dysfunction in animals and
humans, but the underlying mechanisms remain unknown. To investigate the toxic …

Pre- and postnatal exposure to ambient levels of urban particulate matter (PM2.5) affects mice spermatogenesis

A Pires, EN de Melo, T Mauad… - Inhalation …, 2011 - Taylor & Francis
This work characterizes the effects of ambient levels of urban particulate matter (PM2. 5)
from the city of Sao Paulo on spermatogenesis using mice exposed during the embryo–fetal …

PM2. 5 exposure impairs sperm quality through testicular damage dependent on NALP3 inflammasome and miR-183/96/182 cluster targeting FOXO1 in mouse

L Zhou, X Su, B Li, C Chu, H Sun, N Zhang… - Ecotoxicology and …, 2019 - Elsevier
Exposure to ambient fine particular matter (PM2. 5) has been clearly associated with male
reproductive disorders. However, very limited toxicological studies were carried out to …

Analysis by metabolomics and transcriptomics for the energy metabolism disorder and the aryl hydrocarbon receptor activation in male reproduction of mice and GC …

F Shi, Z Zhang, J Wang, Y Wang, J Deng… - Frontiers in …, 2022 - frontiersin.org
Fine particulate matter (PM2. 5)-induced male reproductive toxicity arouses global public
health concerns. However, the mechanisms of toxicity remain unclear. This study aimed to …