[HTML][HTML] Staphylococcus aureus Host Tropism and Its Implications for Murine Infection Models

DM Mrochen, LM Fernandes de Oliveira… - International journal of …, 2020 - mdpi.com
Staphylococcus aureus (S. aureus) is a pathobiont of humans as well as a multitude of
animal species. The high prevalence of multi-resistant and more virulent strains of S. aureus …

[HTML][HTML] Bringing together what belongs together: Optimizing murine infection models by using mouse-adapted Staphylococcus aureus strains

P Trübe, T Hertlein, DM Mrochen, D Schulz… - International Journal of …, 2019 - Elsevier
Staphylococcus (S.) aureus is a leading cause of bacterial infection world-wide, and
currently no vaccine is available for humans. Vaccine development relies heavily on …

Staphylococcus aureus Infection in Humanized Mice: A New Model to Study Pathogenicity Associated With Human Immune Response

J Knop, F Hanses, T Leist, NM Archin… - The Journal of …, 2015 - academic.oup.com
Background. Staphylococcus aureus is a common pathogen among humans worldwide,
with an increasing prevalence of multidrug resistance. The understanding of virulence …

[HTML][HTML] Humanized Mouse Models of Staphylococcus aureus Infection

D Parker - Frontiers in immunology, 2017 - frontiersin.org
Staphylococcus aureus is a successful human pathogen that has adapted itself in response
to selection pressure by the human immune system. A commensal of the human skin and …

Mouse models for infectious diseases caused by Staphylococcus aureus

HK Kim, D Missiakas, O Schneewind - Journal of immunological methods, 2014 - Elsevier
Staphylococcus aureus–a commensal of the human skin, nares and gastrointestinal tract–is
also a leading cause of bacterial skin and soft tissue infection (SSTIs), bacteremia, sepsis …

Latest Advances in the Application of Humanized Mouse Model for Staphylococcus aureus

P Zheng, F Liu, J Long, Y Jin, S Chen… - The Journal of …, 2023 - academic.oup.com
Staphylococcus aureus (S. aureus) is an important pathogen for humans and can cause a
wide range of diseases, from mild skin infections, severe osteomyelitis to fatal pneumonia …

Murine models for staphylococcal infection

N Klopfenstein, JE Cassat, A Monteith, A Miller… - Current …, 2021 - Wiley Online Library
Staphylococcus aureus is a Gram‐positive bacterium that colonizes almost every organ in
humans and mice and is a leading cause of diseases worldwide. S. aureus infections can be …

[HTML][HTML] Models matter: the search for an effective Staphylococcus aureus vaccine

W Salgado-Pabón, PM Schlievert - Nature Reviews Microbiology, 2014 - nature.com
Staphylococcus aureus is a highly successful bacterial pathogen owing to its abundance of
cell surface and secreted virulence factors. It is estimated that 30% of the population is …

[HTML][HTML] Laboratory Mice Are Frequently Colonized with Staphylococcus aureus and Mount a Systemic Immune Response—Note of Caution for In vivo Infection …

D Schulz, D Grumann, P Trübe… - Frontiers in Cellular …, 2017 - frontiersin.org
Whether mice are an appropriate model for S. aureus infection and vaccination studies is a
matter of debate, because they are not considered as natural hosts of S. aureus. We …

[HTML][HTML] Staphylococcus aureus host interactions and adaptation

BP Howden, SG Giulieri, T Wong Fok Lung… - Nature Reviews …, 2023 - nature.com
Invasive Staphylococcus aureus infections are common, causing high mortality,
compounded by the propensity of the bacterium to develop drug resistance. S. aureus is an …