Hypermethylation of the human telomerase catalytic subunit (hTERT) gene correlates with telomerase activity
I Guilleret, P Yan, F Grange… - … journal of cancer, 2002 - Wiley Online Library
DNA methylation is an epigenetic process involved in embryonic development,
differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in …
differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in …
Methylation of the human telomerase gene CpG island
SK Dessain, H Yu, RR Reddel, RL Beijersbergen… - Cancer Research, 2000 - AACR
The acquisition of expression of hTERT, the catalytic subunit of the telomerase enzyme,
seems to be an essential step in the development of a majority of human tumors. However …
seems to be an essential step in the development of a majority of human tumors. However …
DNA Methylation Analysis of the Promoter Region of the Human Telomerase Reverse Transcriptase (hTERT) Gene
TR Devereux, I Horikawa, CH Anna, LA Annab… - Cancer research, 1999 - AACR
The promoter of the hTERT gene encoding the catalytic subunit of telomerase was recently
cloned and has a dense CG-rich CpG island, suggesting a role for methylation in regulation …
cloned and has a dense CG-rich CpG island, suggesting a role for methylation in regulation …
Demethylation of the human telomerase catalytic subunit (hTERT) gene promoter reduced hTERT expression and telomerase activity and shortened telomeres
I Guilleret, J Benhattar - Experimental cell research, 2003 - Elsevier
Telomerase is the ribonucleoproteic complex involved in maintaining telomere size. It is
expressed in germ and stem cells but not in normal somatic cells. In most tumors …
expressed in germ and stem cells but not in normal somatic cells. In most tumors …
Methylation status and expression of human telomerase reverse transcriptase in ovarian and cervical cancer
A Widschwendter, HM Müller, MM Hubalek… - Gynecologic …, 2004 - Elsevier
Objectives. Activation of telomerase, the enzyme that synthesizes the telomere ends of linear
chromosomes, has been implicated in human cell immortalization and cancer cell …
chromosomes, has been implicated in human cell immortalization and cancer cell …
Frequent Amplification of the Telomerase Reverse Transcriptase Gene in Human Tumors
A Zhang, C Zheng, C Lindvall, M Hou, J Ekedahl… - Cancer research, 2000 - AACR
Activation of telomerase is a crucial step during cellular immortalization and malignant
transformation of human cells and requires the induction of the catalytic component, human …
transformation of human cells and requires the induction of the catalytic component, human …
Cloning and Characterization of the Promoter Region of Human Telomerase Reverse Transcriptase Gene
I Horikawa, PLA Cable, C Afshari, JC Barrett - Cancer research, 1999 - AACR
Activation of telomerase is one of the rate-limiting steps in human cell immortalization and
carcinogenesis. Human telomerase is composed of at least two protein subunits and an …
carcinogenesis. Human telomerase is composed of at least two protein subunits and an …
Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene
J Zhu, Y Zhao, S Wang - Protein & cell, 2010 - academic.oup.com
Telomerase expression and telomere maintenance are critical for long-term cell proliferation
and survival, and they play important roles in development, aging, and cancer. Cumulating …
and survival, and they play important roles in development, aging, and cancer. Cumulating …
Amplification of the telomerase reverse transcriptase (hTERT) gene in cervical carcinomas
A Zhang, C Zheng, M Hou, C Lindvall… - Genes …, 2002 - Wiley Online Library
The expression of telomerase reverse transcriptase (hTERT), the catalytic component of the
telomerase complex, is required for activation of telomerase during immortalization and …
telomerase complex, is required for activation of telomerase during immortalization and …
Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)
M Wick, D Zubov, G Hagen - Gene, 1999 - Elsevier
The enzyme telomerase plays a crucial role in cellular proliferation and tumorigenesis. By
adding hexameric repeats to chromosome ends, it prevents telomeric loss and, thus, entry …
adding hexameric repeats to chromosome ends, it prevents telomeric loss and, thus, entry …