DNA methylation is an epigenetic process involved in embryonic development,
differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in …

The acquisition of expression of hTERT, the catalytic subunit of the telomerase enzyme,
seems to be an essential step in the development of a majority of human tumors. However …

The promoter of the hTERT gene encoding the catalytic subunit of telomerase was recently
cloned and has a dense CG-rich CpG island, suggesting a role for methylation in regulation …

Telomerase is the ribonucleoproteic complex involved in maintaining telomere size. It is
expressed in germ and stem cells but not in normal somatic cells. In most tumors …

Objectives. Activation of telomerase, the enzyme that synthesizes the telomere ends of linear
chromosomes, has been implicated in human cell immortalization and cancer cell …

Activation of telomerase is a crucial step during cellular immortalization and malignant
transformation of human cells and requires the induction of the catalytic component, human …

Activation of telomerase is one of the rate-limiting steps in human cell immortalization and
carcinogenesis. Human telomerase is composed of at least two protein subunits and an …

Telomerase expression and telomere maintenance are critical for long-term cell proliferation
and survival, and they play important roles in development, aging, and cancer. Cumulating …

The expression of telomerase reverse transcriptase (hTERT), the catalytic component of the
telomerase complex, is required for activation of telomerase during immortalization and …

The enzyme telomerase plays a crucial role in cellular proliferation and tumorigenesis. By
adding hexameric repeats to chromosome ends, it prevents telomeric loss and, thus, entry …