Chemically Modified Oligonucleotides: Synthesis, Physicochemical and Biochemical Properties of their Duplexes with DNA and RNA
PI Pradeepkumar - 2004 - diva-portal.org
This thesis is based on 9 papers dealing with the synthesis, physicochemical and
biochemical properties of two types of chemically modified oligonucleotides which have the …
biochemical properties of two types of chemically modified oligonucleotides which have the …
Comparison of the RNase H Cleavage Kinetics and Blood Serum Stability of the North-Conformationally Constrained and 2'-Alkoxy Modified Oligonucleotides
D Honcharenko, J Barman, OP Varghese… - Biochemistry, 2007 - ACS Publications
The RNase H cleavage potential of the RNA strand basepaired with the complementary
antisense oligonucleotides (AONs) containing North− East conformationally constrained 1 ' …
antisense oligonucleotides (AONs) containing North− East conformationally constrained 1 ' …
Oxetane modified antisense oligonucleotides promote RNase H cleavage of the complementary RNA strand in the hybrid duplex as efficiently as the native, and offer …
PI Pradeepkumar, J Chattopadhyaya - Journal of the Chemical Society …, 2001 - pubs.rsc.org
Although the Tm drops∼ 6° C/modification (note: Tm loss is∼ 10° C/mismatch) in the
oxetane,[1-(1′, 3′-O-anhydro-β-D-psicofuranosyl) thymine, text-decoration: underline'T] …
oxetane,[1-(1′, 3′-O-anhydro-β-D-psicofuranosyl) thymine, text-decoration: underline'T] …
[PDF][PDF] New methylene-bridged hexopyranosyl nucleoside modified oligonucleotides (BHNA): synthesis and biochemical studies.
C Zhou, J Chattopadhyaya - ARKIVOC: Online Journal of …, 2009 - pdfs.semanticscholar.org
The hyper-constrained nucleoside, methylene-bridged hexopyranosyl nucleoside (BHNA)
was incorporated into the antisnese oligonucleotides (AON), which show more preference …
was incorporated into the antisnese oligonucleotides (AON), which show more preference …
Synthesis, Physicochemical and Biochemical Studies of 1 ', 2 '-Oxetane Constrained Adenosine and Guanosine Modified Oligonucleotides, and Their Comparison …
PI Pradeepkumar, P Cheruku… - Journal of the …, 2004 - ACS Publications
We have earlier reported the synthesis and antisense properties of the conformationally
constrained oxetane-C and-T containing oligonucleotides, which have shown effective down …
constrained oxetane-C and-T containing oligonucleotides, which have shown effective down …
Antisense oligonuclotides with oxetane-constrained cytidine enhance heteroduplex stability, and elicit satisfactory RNase H response as well as showing improved …
PI Pradeepkumar, NV Amirkhanov… - Organic & biomolecular …, 2003 - pubs.rsc.org
Antisense oligonucleotides (AONs) with single and double oxetane modifications [1′, 2′-
oxetane constrained cytidine, 1-(1′, 3′-O-anhydro-β-D-psicofuranosyl) cytosine] have …
oxetane constrained cytidine, 1-(1′, 3′-O-anhydro-β-D-psicofuranosyl) cytosine] have …
[引用][C] Replacement of the Negative Phosphodiester Linkages of DNA by Positive S-Methylthiourea Linkers: A Novel Approach to Putative Antisense Agents
DP Arya, TC Bruice - Journal of the American Chemical Society, 1998 - ACS Publications
Antisense oligonucleotides with various backbone modifications have attracted
considerable attention. 1-4 Among other requirements, successful development of antisense …
considerable attention. 1-4 Among other requirements, successful development of antisense …
2'-O-[2-[2-(N,N-Dimethylamino)ethoxy]ethyl] Modified Oligonucleotides: Symbiosis of Charge Interaction Factors and Stereoelectronic Effects
M Prhavc, TP Prakash, G Minasov, PD Cook… - Organic …, 2003 - ACS Publications
Oligonucleotides with a novel, 2 '-O-[2-[2-(N, N-dimethylamino) ethoxy] ethyl](2 '-O-
DMAEOE) modification have been synthesized. This modification, a cationic analogue of the …
DMAEOE) modification have been synthesized. This modification, a cationic analogue of the …
Correlating Structure and Stability of DNA Duplexes with Incorporated 2'-O-Modified RNA Analogues,
V Tereshko, S Portmann, EC Tay, P Martin, F Natt… - Biochemistry, 1998 - ACS Publications
Chemically modified nucleic acids are currently being evaluated as potential antisense
compounds for therapeutic applications. 2 '-O-Ethylene glycol substituted …
compounds for therapeutic applications. 2 '-O-Ethylene glycol substituted …
Fine tuning of electrostatics around the internucleotidic phosphate through incorporation of modified 2′, 4′-carbocyclic-LNAs and-ENAs leads to significant …
C Zhou, Y Liu, M Andaloussi, N Badgujar… - The Journal of …, 2009 - ACS Publications
In the antisense (AS) and RNA interference (RNAi) technologies, the native single-stranded
2′-deoxyoligonucleotides (for AS) or double-stranded RNA (for RNAi) are chemically …
2′-deoxyoligonucleotides (for AS) or double-stranded RNA (for RNAi) are chemically …