Activation of the NLRP3 inflammasome and its mediated neuroinflammation are implicated
in neurodegenerative diseases, while mitophagy negatively regulates NLRP3 …

Purpose Neurodegenerative diseases are associated with neuroinflammation along with
activation of microglia and oxidative stress, but currently lack effective treatments …

Emerging evidence indicates that the enhancement of microglial autophagy inhibits the
NLRP3 inflammasome mediated neuroinflammation in Alzheimer's disease (AD) …

Aging-related, nonresolving inflammation in both the central nervous system (CNS) and
periphery predisposes individuals to the development of neurodegenerative disorders …

Inflammation plays a key role in the pathogenesis of depression and antidepressant
therapies. Astragalin (AST) is a bioactive flavonoid that possesses an anti-inflammatory …

Neuroinflammation related to microglial activation plays an important role in
neurodegenerative diseases. Translocator protein 18 kDa (TSPO), a biomarker of reactive …

Cellular communication linking microglia activation and dopaminergic neuronal loss play an
imperative role in the progression of Parkinson's disease (PD); however, underlying …

Alzheimer's disease (AD) is an irreversible neurodegenerative brain disorder with complex
pathogenesis. The fibrillar peptide β-amyloid (Aβ) has a chief function in the pathogenesis of …

Obesity is characterized by a condition of low-grade chronic inflammation that facilitates
development of numerous comorbidities and dysregulation of brain homeostasis. It is …

Background Emerging evidence indicates that nod-like receptor family, pyrin domain-
containing 3 (NLRP3) inflammasome-induced inflammation plays a crucial role in the …