It was recently shown that the major genetic risk factor associated with becoming severely ill
with COVID-19 when infected by severe acute respiratory syndrome coronavirus 2 (SARS …

A recent genetic association study identified a gene cluster on chromosome 3 as a risk locus
for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 …

The genetic make-up of an individual contributes to the susceptibility and response to viral
infection. Although environmental, clinical and social factors have a role in the chance of …

Background The severity of coronavirus disease 2019 (COVID-19) caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly heterogeneous. Studies …

COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to
fatal in others. Based on a study of 1,051,032 23andMe research participants, we report …

The COVID-19 pandemic continues to pose a major public health threat, especially in
countries with low vaccination rates. To better understand the biological underpinnings of …

The host response to SARS-CoV-2, the etiologic agent of the COVID-19 pandemic,
demonstrates significant interindividual variability. In addition to showing more disease in …

Background The emergence of the novel coronavirus in Wuhan, Hubei Province, China, in
December 2019 marked the synchronization of the world to a peculiar clock that is counting …

Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …

Unprecedented public health interventions including travel restrictions and national
lockdowns have been implemented to stem the COVID-19 epidemic, but the effectiveness of …