Clinical Drugs that Interact with St. John's Wort and mplication in Drug Development

YM Di, CG Li, CC Xue, SF Zhou - Current pharmaceutical …, 2008 - ingentaconnect.com
St. John's wort (Hypericum perforatum, SJW) is one of the most commonly used herbal
antidepressants for the treatment of minor to moderate depression. A major safety concern …

An update on clinical drug interactions with the herbal antidepressant St. John's wort

SF Zhou, X Lai - Current drug metabolism, 2008 - ingentaconnect.com
St. John's wort (Hypericum perforatum, SJW) is one of the most commonly used herbal
antidepressants for the treatment of minor to moderate depression. Limited clinical trials …

Clinical relevance of St. John's wort drug interactions revisited

S Nicolussi, J Drewe, V Butterweck… - British journal of …, 2020 - Wiley Online Library
The first clinically relevant reports of preparations of St. John's wort (SJW), a herbal medicine
with anti‐depressant effects, interacting with other drugs, altering their bioavailability and …

Drug interactions with St. John's Wort (Hypericum perforatum): a review of the clinical evidence.

AA Izzo - International journal of clinical pharmacology and …, 2004 - europepmc.org
St. John's Wort (SJW, Hypericum perforatum) is effective in mild-to-moderate depression. As
a monotherapy, SJW has an encouraging safety profile. However, numerous reports indicate …

Clinical risks of St John's Wort (Hypericum perforatum) co-administration

S Soleymani, R Bahramsoltani, R Rahimi… - Expert opinion on …, 2017 - Taylor & Francis
ABSTRACT Introduction: St. John's wort (SJW) is a common medicinal herb used for the
treatment of mild to moderate depression. Hyperforin, one of the chief components of SJW …

Herb–Drug Interactions with St John's Wort (Hypericum perforatum): an Update on Clinical Observations

F Borrelli, AA Izzo - The AAPS journal, 2009 - Springer
St John's wort (SJW) extracts, prepared from the aerial parts of Hypericum perforatum,
contain numerous pharmacologically active ingredients, including naphthodianthrones (eg …

Molecular mechanisms underlying St. John's wort drug interactions

M Kober, K Pohl, T Efferth - Current drug metabolism, 2008 - ingentaconnect.com
The phytopharmaceutical agent St. John's wort (SJW) is currently under intense
investigation. Studies of drug interactions resulting from concomitant use of SJW and …

Pharmacokinetic interactions of drugs with St John's wort

S Zhou, E Chan, SQ Pan, M Huang… - Journal of …, 2004 - journals.sagepub.com
There is a worldwide increasing use of herbs which are often administered in combination
with therapeutic drugs, raising the potential for herb-drug interactions. St John's wort …

Drug interactions with St John's wort: mechanisms and clinical implications

M Mannel - Drug safety, 2004 - Springer
The purpose of this paper is to review preclinical and clinical evidence relating to drug
interactions with preparations of the medicinal herb St John's wort (Hypericum perforatum) …

Drug interaction between St John's wort and zolpidem in healthy subjects

Y Hojo, M Echizenya, T Ohkubo… - Journal of clinical …, 2011 - Wiley Online Library
What is known and objective: St John's wort (SJW, Hypericum perforatum) is one of the most
commonly used herbal antidepressants for treatment of mild to moderate depression. SJW …