Arrestins are multifunctional proteins that regulate G-protein-coupled receptor (GPCR)
desensitization, signaling, and internalization. The arrestin family consists of four subtypes …

Abstract β-arrestins represent a small family of G protein-coupled receptors (GPCRs)
regulators, which provide modulating effects by facilitating desensitization and …

β-arrestins, which have multiple cellular functions, were initially described as proteins that
desensitize rhodopsin and other G protein-coupled receptors. The cytoskeletal system plays …

Abstract β-Arrestins 1 and 2 are ubiquitously expressed proteins that play a dual role in G
protein-coupled receptor (GPCR) signaling. On the one hand, arrestins are central to the …

Multiple G protein-coupled receptors (GPCRs) are targets in the treatment of dementia, and
the arrestins are common to their signaling. β-Arrestin2 was significantly increased in brains …

Arrestins are versatile regulators of cellular signaling expressed in every cell in the body.
Arrestins bind active phosphorylated forms of their cognate G-protein-coupled receptors …

α-Arrestins, also called arrestin-related trafficking adaptors (ARTs), constitute a large family
of proteins conserved from yeast to humans. Despite their evolutionary precedence over …

The visual/β-arrestins, a small family of proteins originally described for their role in the
desensitization and intracellular trafficking of G protein–coupled receptors (GPCRs), have …

Biological activity of free arrestins is often overlooked. Based on available data, we compare
arrestin-mediated signaling that requires and does not require binding to G-protein-coupled …

The two β-arrestins, β-arrestin-1 and-2 (systematic names: arrestin-2 and-3, respectively),
are multifunctional intracellular proteins that regulate the activity of a very large number of …