[HTML][HTML] Perspectives on the Role of Isoliquiritigenin in Cancer

KL Wang, YC Yu, SM Hsia - Cancers, 2021 - mdpi.com
Simple Summary Isoliquiritigenin (ISL), a natural bioactive compound with a chalcone
structure, demonstrates high antitumor efficacy. This review presents a summary of the latest …

Isoliquiritigenin (ISL) and its formulations: potential antitumor agents

TT Zhao, YQ Xu, HM Hu, HB Gong… - Current Medicinal …, 2019 - ingentaconnect.com
Isoliquiritigenin (2', 4', 4-trihydroxychalcone, ISL) is one of the most important chalcone
compounds which is mainly derived from licorice root and many other plants. It exhibits a …

A review: the pharmacology of isoliquiritigenin

F Peng, Q Du, C Peng, N Wang, H Tang… - Phytotherapy …, 2015 - Wiley Online Library
Isoliquiritigenin (ISL) is one of the bioactive ingredients isolated from the roots of plants
belonging to licorice, including Glycyrrhiza uralensis, Mongolian glycyrrhiza, Glycyrrhiza …

[HTML][HTML] Therapeutic intervention in cancer by isoliquiritigenin from licorice: a natural antioxidant and redox regulator

Z Zhang, KKL Yung, JKS Ko - Antioxidants, 2022 - mdpi.com
Oxidative stress could lead to a variety of body dysfunctions, including neurodegeneration
and cancer, which are closely associated with intracellular signal transducers such as …

[HTML][HTML] Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells by suppressing the PI3K/AKT/mTOR signaling pathway

XR Zhang, SY Wang, W Sun… - Molecular medicine …, 2018 - spandidos-publications.com
Isoliquiritigenin (ISL) is a flavonoid extracted from licorice root, which is known to serve
important antitumor roles in numerous types of cancers; however, its effect on gastric cancer …

Antineoplastic activity of isoliquiritigenin, a chalcone compound, in androgen-independent human prostate cancer cells linked to G2/M cell cycle arrest and cell …

B Zhang, Y Lai, Y Li, N Shu, Z Wang, Y Wang… - European Journal of …, 2018 - Elsevier
Isoliquiritigenin is a natural chalcone derived from Glycyrrhiza, which has been reported to
have anti-tumor activity in recent years. Here, we investigate the anticancer efficacy and …

In vitro metabolism of isoliquiritigenin by human liver microsomes

J Guo, D Liu, D Nikolic, D Zhu, JM Pezzuto… - Drug metabolism and …, 2008 - ASPET
Isoliquiritigenin (2′, 4′, 4-trihydroxychalcone), a chalcone found in licorice root and other
plants, has shown potent antitumor, antioxidant, and phytoestrogenic activity in vitro. In …

Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights

R Jain, MA Hussein, S Pierce, C Martens… - Pharmacological …, 2022 - Elsevier
Licorice (Glycyrrhiza glabra) is a well-known natural herb used to treat different ailments
since ancient times. Glycyrrhizin (GL), which is the primary triterpenoid compound of licorice …

Pharmacokinetics of isoliquiritigenin and its metabolites in rats: low bioavailability is primarily due to the hepatic and intestinal metabolism

YK Lee, YW Chin, JK Bae, JS Seo, YH Choi - Planta Medica, 2013 - thieme-connect.com
Isoliquiritigenin, a chalcone found in licorice has shown a variety of biological activities
including antioxidative, anti-inflammatory, estrogenic, chemopreventive and antitumor …

Isoliquiritigenin, a natural anti‐oxidant, selectively inhibits the proliferation of prostate cancer cells

X Zhang, ED Yeung, J Wang… - Clinical and …, 2010 - Wiley Online Library
Isoliquiritigenin (ISL) is a simple chalcone‐type flavonoid derived from liquorice compounds.
It has been reported to have anti‐oxidative and antitumour activities. The aim of the present …