There are five fibroblast growth factor receptors (FGFRs), namely, FGFR1–FGFR5. When
FGFR binds to its ligand, namely, fibroblast growth factor (FGF), it dimerizes and …

Simple Summary All cells within tissues and organ systems must communicate with each
other to ensure they function in a coordinated manner. One form of communication is …

The fibroblast growth factor signaling pathway (FGFR signaling) is an evolutionary
conserved signaling cascade that regulates several basic biologic processes, including …

The discovery of oncogenic driver mutations and the subsequent developments in targeted
therapies have led to improved outcomes for subsets of lung cancer patients. The …

Abstract Introduction The Fibroblast Growth Factor Receptor (FGFR) family consists of
Tyrosine Kinase Receptors (TKR) involved in several biological functions. Recently …

Fibroblast growth factor receptors (FGFRs), encoded by four genes (FGFR1, FGFR2, FGFR3,
and FGFR4) are tightly associated with many biological processes such as organ …

The fibroblast growth factor receptors (FGFR) play essential roles both during development
and in the adult. Upon ligand binding, FGFRs induce intracellular signaling networks that …

FGFRs are receptor tyrosine kinases with a role in several biological processes, such as the
regulation of development and tissue repair. However, alterations in FGFRs 1–4, such as …

The four receptor tyrosine kinases (RTKs) within the family of Fibroblast Growth Factor
Receptors (FGFRs) are critical for normal development but also play an enormous role in …

Increasing evidence indicates that success of targeted therapies in the treatment of cancer is
context-dependent and is influenced by a complex crosstalk between signaling pathways …