Many patients with systemic immune-inflammatory and neuro-inflammatory disorders,
including depression, rheumatoid arthritis, systemic lupus erythematosus, Sjögren's disease …

Background The genesis of severe fatigue and disability in people following acute pathogen
invasion involves the activation of Toll-like receptors followed by the upregulation of …

Profound and debilitating fatigue is the most common complaint reported among individuals
with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 …

The exact nature and pathophysiology of fatigue remain largely elusive despite its high
prevalence in physically ill patients. Studies on the relationship between the immune system …

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating multi-
systemic chronic illness of unknown etiology, classified as a neurological disorder by the …

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS) is a complex, multisystem
disease that is characterized by long-term fatigue, exhaustion, disabilities, pain …

Multiple sclerosis (MS) is an immune mediated disease of the central nervous system (CNS)
and the leading cause of non-traumatic disability among young and middle-aged adults in …

Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) has been classified as a
disease of the central nervous system by the WHO since 1969. Many patients carrying this …

The focus on fatigue for the 2012 Named Series in brain, behavior, and immunity reflects the
growing wave of research examining immune underpinnings of fatigue in healthy and …

There is evidence that immune-inflammatory and oxidative and nitrosative stress (O&NS)
pathways play a role in the pathophysiology of myalgic encephalomyelitis (ME)/chronic …