[HTML][HTML] The timing of the excitatory-to-inhibitory GABA switch is regulated by the oxytocin receptor via KCC2

M Leonzino, M Busnelli, F Antonucci, C Verderio… - Cell reports, 2016 - cell.com
Oxytocin and its receptor (Oxtr) play a crucial role in the postnatal transition of neuronal
GABA neurotransmission from excitatory to inhibitory, a developmental process known as …

Effects of oxytocin on GABA signalling in the foetal brain during delivery

R Khazipov, R Tyzio, Y Ben-Ari - Progress in brain research, 2008 - Elsevier
Oxytocin (OXT) exerts multiple effects in the adult central nervous system. However, little is
known about the effects of OXT on foetal neurons during delivery, at the time when a surge …

Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons

S Ripamonti, MC Ambrozkiewicz, F Guzzi, M Gravati… - Elife, 2017 - elifesciences.org
Beyond its role in parturition and lactation, oxytocin influences higher brain processes that
control social behavior of mammals, and perturbed oxytocin signaling has been linked to the …

Oxytocin receptor ligand binding in embryonic tissue and postnatal brain development of the C57BL/6J mouse

EAD Hammock, P Levitt - Frontiers in behavioral neuroscience, 2013 - frontiersin.org
Oxytocin (OXT) has drawn increasing attention as a developmentally relevant neuropeptide
given its role in the brain regulation of social behavior. It has been suggested that OXT plays …

Oxytocin-modulated ion channel ensemble controls depolarization, integration and burst firing in CA2 pyramidal neurons

JJ Liu, KW Eyring, GM König, E Kostenis… - Journal of …, 2022 - Soc Neuroscience
Oxytocin (OXT) and OXT receptor (OXTR)-mediated signaling control excitability, firing
patterns, and plasticity of hippocampal CA2 pyramidal neurons, which are pivotal in …

Oxytocin receptor expression patterns in the human brain across development

J Rokicki, T Kaufmann, AMG De Lange… - …, 2022 - nature.com
Oxytocin plays a vital role in social behavior and homeostatic processes, with animal models
indicating that oxytocin receptor (OXTR) expression patterns in the brain influence behavior …

Novel repression of Kcc2 transcription by REST–RE-1 controls developmental switch in neuronal chloride

M Yeo, K Berglund, G Augustine… - Journal of …, 2009 - Soc Neuroscience
Transcriptional upregulation of Kcc2b, the gene variant encoding the major isoform of the
KCC2 chloride transporter, underlies a rapid perinatal decrease in intraneuronal chloride …

Oxytocin transforms firing mode of CA2 hippocampal neurons

NN Tirko, KW Eyring, I Carcea, M Mitre, MV Chao… - Neuron, 2018 - cell.com
Oxytocin is an important neuromodulator in the mammalian brain that increases information
salience and circuit plasticity, but its signaling mechanisms and circuit effect are not fully …

Oxytocin as a modulator of synaptic plasticity: implications for neurodevelopmental disorders

KT Rajamani, S Wagner, V Grinevich… - Frontiers in synaptic …, 2018 - frontiersin.org
The neuropeptide oxytocin (OXT) is a crucial mediator of parturition and milk ejection and a
major modulator of various social behaviors, including social recognition, aggression and …

Newborn analgesia mediated by oxytocin during delivery

M Mazzuca, M Minlebaev, A Shakirzyanova… - Frontiers in cellular …, 2011 - frontiersin.org
The mechanisms controlling pain in newborns during delivery are poorly understood. We
explored the hypothesis that oxytocin, an essential hormone for labor and a powerful …