Aims To estimate the prevalence and burden of disease attributable to opioid dependence
globally, regionally and at country level. Methods Multiple search strategies:(i) peer …

Design: Systematic review and meta-analysis of cohorts of people with OUD involving illicit
opioids with data on all-cause or overdose-specific mortality. Setting and Participants: Of …

We summarise the evidence for medicinal uses of opioids, harms related to the extramedical
use of, and dependence on, these drugs, and a wide range of interventions used to address …

Aims To estimate mortality rates among treated opioid‐dependent individuals by cause and
in relation to the general population, and to estimate the instantaneous effects of opioid …

Background The USA is currently facing a serious opioid misuse epidemic that started with
increased prescribing of oxycodone and the inclusion of pain as a fifth vital sign, and …

Introduction: The consumption of opioids has increased globally since the 1990s. Previous
studies of global opioid consumption have concentrated on morphine alone or a subset of …

Abstract Introduction South Africa has seen a sharp increase in treatment admission trends
for opioids despite beliefs that rates of opioid use remain low and do not represent a major …

Use of illicit opioids and misuse of prescription opioids are the main causes of drug-related
deaths across the world, and the continuing rise in opioid-related mortality, especially …

Background No systematic attempts have been made to estimate the global and regional
prevalence of amphetamine, cannabis, cocaine, and opioid dependence, and quantify their …

Background Globally, opioid drug use is an important cause of premature mortality. In many
countries, opioid using populations are ageing. The current study investigates mortality in a …