Piperidines are among the most important synthetic fragments for designing drugs and play
a significant role in the pharmaceutical industry. Their derivatives are present in more than …

Piperidine, one of the simplest heterocyclic systems, is found in nature as part of several
alkaloid compounds. Both natural and especially unnatural piperidine derivatives present …

Piperazine is one of the most sought heterocyclics for the development of new drug
candidates. This ring can be traced in a number of well established, commercially available …

This review summarizes the in vitro and in vivo medicinal chemistry investigations for
piperazine and morpholine analogues. Piperazine and morpholine nucleus show a broad …

The piperidine ring is an ubiquitous structural feature of many alkaloid natural products and
drug candidates. Watson et al. asserted that during a recent 10-year period there were …

Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug
discovery, including derivative chemistry, structural properties, methods of synthesis and …

Medicinal chemistry is a science applied to the search and discovery of new therapeutic
agents for the treatment of various diseases. Therefore, promising structures have been …

Piperazine moiety is a cyclic molecule containing two nitrogen atoms in positions 1 and 4, as
well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the …

Background Piperidine is an essential heterocyclic system and a pivotal cornerstone in the
production of drugs. Piperidine byproducts showed several important pharmacophoric …

Functionalised piperidines are among the most common building blocks in natural products,
and, more interestingly, in many biologically active compounds such as anopterine …