Using ecological coexistence theory to understand antibiotic resistance and microbial competition
Tackling antibiotic resistance necessitates deep understanding of how resource competition
within and between species modulates the fitness of resistant microbes. Recent advances in …
within and between species modulates the fitness of resistant microbes. Recent advances in …
Antibiotic resistance in bacterial communities
M Denk-Lobnig, KB Wood - Current opinion in microbiology, 2023 - Elsevier
Bacteria are single-celled organisms, but the survival of microbial communities relies on
complex dynamics at the molecular, cellular, and ecosystem scales. Antibiotic resistance, in …
complex dynamics at the molecular, cellular, and ecosystem scales. Antibiotic resistance, in …
Within-host dynamics shape antibiotic resistance in commensal bacteria
The spread of antibiotic resistance, a major threat to human health, is poorly understood.
Simple population-level models of bacterial transmission predict that above a certain rate of …
Simple population-level models of bacterial transmission predict that above a certain rate of …
Antibiotic resistance in the wild: an eco-evolutionary perspective
The legacy of the use and misuse of antibiotics in recent decades has left us with a global
public health crisis: antibiotic-resistant bacteria are on the rise, making it harder to treat …
public health crisis: antibiotic-resistant bacteria are on the rise, making it harder to treat …
Ecology and evolution of antimicrobial resistance in bacterial communities
Accumulating evidence suggests that the response of bacteria to antibiotics is significantly
affected by the presence of other interacting microbes. These interactions are not typically …
affected by the presence of other interacting microbes. These interactions are not typically …
Metabolic fitness landscapes predict the evolution of antibiotic resistance
Bacteria evolve resistance to antibiotics by a multitude of mechanisms. A central, yet
unsolved question is how resistance evolution affects cell growth at different drug levels …
unsolved question is how resistance evolution affects cell growth at different drug levels …
Microbial interspecies interactions and their impact on the emergence and spread of antimicrobial resistance
G De Wit, L Svet, B Lories… - Annual Review of …, 2022 - annualreviews.org
Bacteria are social organisms that commonly live in dense communities surrounded by a
multitude of other species. The competitive and cooperative interactions between these …
multitude of other species. The competitive and cooperative interactions between these …
Novel insights into selection for antibiotic resistance in complex microbial communities
Recent research has demonstrated that selection for antibiotic resistance occurs at very low
antibiotic concentrations in single-species experiments, but the relevance of these findings …
antibiotic concentrations in single-species experiments, but the relevance of these findings …
The ecology and evolution of microbial competition
Microbes are typically surrounded by different strains and species with whom they compete
for scarce nutrients and limited space. Given such challenging living conditions, microbes …
for scarce nutrients and limited space. Given such challenging living conditions, microbes …
Why do antibiotics exist?
F Spagnolo, M Trujillo, JJ Dennehy - Mbio, 2021 - Am Soc Microbiol
In the struggle with antibiotic resistance, we are losing. There is now a serious threat of
moving into a postantibiotic world. High levels of resistance, in terms of both frequency and …
moving into a postantibiotic world. High levels of resistance, in terms of both frequency and …