Using ecological coexistence theory to understand antibiotic resistance and microbial competition

AD Letten, AR Hall, JM Levine - Nature ecology & evolution, 2021 - nature.com
Tackling antibiotic resistance necessitates deep understanding of how resource competition
within and between species modulates the fitness of resistant microbes. Recent advances in …

Antibiotic resistance in bacterial communities

M Denk-Lobnig, KB Wood - Current opinion in microbiology, 2023 - Elsevier
Bacteria are single-celled organisms, but the survival of microbial communities relies on
complex dynamics at the molecular, cellular, and ecosystem scales. Antibiotic resistance, in …

Within-host dynamics shape antibiotic resistance in commensal bacteria

NG Davies, S Flasche, M Jit, KE Atkins - Nature ecology & evolution, 2019 - nature.com
The spread of antibiotic resistance, a major threat to human health, is poorly understood.
Simple population-level models of bacterial transmission predict that above a certain rate of …

Antibiotic resistance in the wild: an eco-evolutionary perspective

T Hiltunen, M Virta, AL Laine - … Transactions of the …, 2017 - royalsocietypublishing.org
The legacy of the use and misuse of antibiotics in recent decades has left us with a global
public health crisis: antibiotic-resistant bacteria are on the rise, making it harder to treat …

Ecology and evolution of antimicrobial resistance in bacterial communities

MJ Bottery, JW Pitchford, VP Friman - The ISME Journal, 2021 - academic.oup.com
Accumulating evidence suggests that the response of bacteria to antibiotics is significantly
affected by the presence of other interacting microbes. These interactions are not typically …

Metabolic fitness landscapes predict the evolution of antibiotic resistance

F Pinheiro, O Warsi, DI Andersson… - Nature Ecology & …, 2021 - nature.com
Bacteria evolve resistance to antibiotics by a multitude of mechanisms. A central, yet
unsolved question is how resistance evolution affects cell growth at different drug levels …

Microbial interspecies interactions and their impact on the emergence and spread of antimicrobial resistance

G De Wit, L Svet, B Lories… - Annual Review of …, 2022 - annualreviews.org
Bacteria are social organisms that commonly live in dense communities surrounded by a
multitude of other species. The competitive and cooperative interactions between these …

Novel insights into selection for antibiotic resistance in complex microbial communities

AK Murray, L Zhang, X Yin, T Zhang, A Buckling… - MBio, 2018 - Am Soc Microbiol
Recent research has demonstrated that selection for antibiotic resistance occurs at very low
antibiotic concentrations in single-species experiments, but the relevance of these findings …

The ecology and evolution of microbial competition

M Ghoul, S Mitri - Trends in microbiology, 2016 - cell.com
Microbes are typically surrounded by different strains and species with whom they compete
for scarce nutrients and limited space. Given such challenging living conditions, microbes …

Why do antibiotics exist?

F Spagnolo, M Trujillo, JJ Dennehy - Mbio, 2021 - Am Soc Microbiol
In the struggle with antibiotic resistance, we are losing. There is now a serious threat of
moving into a postantibiotic world. High levels of resistance, in terms of both frequency and …