Docking, synthesis, and NMR studies of mannosyl trisaccharide ligands for DC-SIGN lectin

JJ Reina, I Díaz, PM Nieto, NE Campillo… - Organic & …, 2008 - pubs.rsc.org
DC-SIGN, a lectin, which presents at the surface of immature dendritic cells, constitutes
nowadays a promising target for the design of new antiviral drugs. This lectin recognizes …

1, 2‐Mannobioside mimic: synthesis, DC‐SIGN interaction by NMR and docking, and antiviral activity

JJ Reina, S Sattin, D Invernizzi, S Mari… - ChemMedChem …, 2007 - Wiley Online Library
The design and preparation of carbohydrate ligands for DC‐SIGN is a topic of high interest
because of the role played by this C‐type lectin in immunity and infection processes. The …

Unique DC-SIGN clustering activity of a small glycomimetic: A lesson for ligand design

I Sutkeviciute, M Thépaut, S Sattin, A Berzi… - ACS chemical …, 2014 - ACS Publications
DC-SIGN is a dendritic cell-specific C-type lectin receptor that recognizes highly
glycosylated ligands expressed on the surface of various pathogens. This receptor plays an …

Structure of a glycomimetic ligand in the carbohydrate recognition domain of C-type lectin DC-SIGN. Structural requirements for selectivity and ligand design

M Thépaut, C Guzzi, I Sutkeviciute… - Journal of the …, 2013 - ACS Publications
In genital mucosa, different fates are described for HIV according to the subtype of dendritic
cells (DCs) involved in its recognition. This notably depends on the C-type lectin receptor …

Mannosylcalix [n] arenes as multivalent ligands for DC-SIGN

I Morbioli, V Porkolab, A Magini, A Casnati… - Carbohydrate …, 2017 - Elsevier
DC-SIGN is a receptor protruded from the membrane of immature dendritic cells (DCs) that
participates in the activation of the immune response through the recognition of pathogen …

Monovalent mannose-based DC-SIGN antagonists: Targeting the hydrophobic groove of the receptor

T Tomašić, D Hajšek, U Švajger, J Luzar… - European Journal of …, 2014 - Elsevier
Dendritic cell-specific, intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is
a C-type lectin expressed specifically on dendritic cells. It is a primary site for recognition …

Polyvalent C-glycomimetics based on L-fucose or D-mannose as potent DC-SIGN antagonists

B Bertolotti, I Sutkeviciute, M Ambrosini… - Organic & …, 2017 - pubs.rsc.org
The C-type lectin DC-SIGN expressed on immature dendritic cells is a promising target for
antiviral drug development. Previously, we have demonstrated that mono-and divalent C …

Stereoselective innovative synthesis and biological evaluation of new real carba analogues of minimal epitope Manα (1, 2) Man as DC-SIGN inhibitors

V Bordoni, V Porkolab, S Sattin, M Thépaut, I Frau… - RSC …, 2016 - pubs.rsc.org
Antagonists of the C-type lectin DC-SIGN are promising therapeutic agents against viruses
and bacteria. The development of glycomimetic ligands for DC-SIGN has so far proved to be …

[PDF][PDF] Saturation transfer difference (STD) NMR spectroscopy characterization of dual binding mode of a mannose disaccharide to DC-SIGN

J Angulo, I Díaz, JJ Reina, G Tabarani, F Fieschi… - …, 2008 - academia.edu
Saturation transfer difference NMR spectroscopy (STD-NMR), together with transfer NOE, is
one of the most widespread NMR methods for the study of the interactions between small …

Solution NMR analyses of the C-type carbohydrate recognition domain of DC-SIGNR protein reveal different binding modes for HIV-derived oligosaccharides and …

F Probert, SBM Whittaker, M Crispin, DA Mitchell… - Journal of Biological …, 2013 - ASBMB
The C-type lectin DC-SIGNR (dendritic cell-specific ICAM-3-grabbing non-integrin-related;
also known as L-SIGN or CD299) is a promising drug target due to its ability to promote …