Objectives The objective of this study was to propose an optimal treatment regimen of
meropenem in critically ill patients with severe nosocomial pneumonia. Patients and …

The time that concentrations in serum are above the MIC (T> MIC) is the pharmacokinetic/
pharmacodynamic parameter correlating with the therapeutic efficacy of β-lactam antibiotics …

Background Optimal antimicrobial drug exposure in the lung is required for successful
treatment outcomes for nosocomial pneumonia. Little is known about the intrapulmonary …

Critically ill patients are characterized by substantial pathophysiological changes that alter
the pharmacokinetics (PK) of hydrophilic antibiotics, including carbapenems. Meropenem is …

The worrisome increase in Gram-negative bacteria with borderline susceptibility to
carbapenems and of carbapenemase-producing Enterobacteriaceae has significantly …

Background Meropenem plasma concentration above a pathogen's MIC over the whole
dosing interval (100% ƒ T> MIC) is a determinant of outcome in severe infections. Significant …

Purpose This study aimed to develop a population pharmacokinetic (PPK) model for
meropenem to optimize dosing regimens for critically ill patients with pulmonary infection …

This study was a pharmacokinetic (PK)–pharmacodynamic (PD) target attainment analysis
of meropenem in Japanese adult patients. Plasma drug concentration data (265 samples …

Objectives The use of extended intermittent infusion (EII) or continuous infusion (CI) of
meropenem is recommended in intensive care unit (ICU) patients, but few data comparing …

The aim of this study was to investigate optimal loading doses prior to continuous infusion of
meropenem in critically ill patients. A previously published and successfully evaluated …