The etiology of autoimmune diseases remains largely unknown. Concordance rates in
monozygotic twins are lower than 50% while genome-wide association studies propose …

Autoimmune diseases are complex disorders of largely unknown etiology. Genetic studies
have identified a limited number of causal genes from a marginal number of individuals, and …

Autoimmune diseases are complex and enigmatic, and have presented particular
challenges to researchers seeking to define their etiology and explain progression. Previous …

Genome-wide association studies have revealed several genes predisposing to
autoimmunity, however, concordance rates in monozygotic twins are significantly below …

Epigenetics is the study of heritable changes in genome function without underlying
modifications in their nucleotide sequence. Disorders of epigenetic processes, which involve …

Accumulating epidemiological, clinical, and experimental evidence supports the conclusion
of a critical role of epigenetic factors in immune programming. This understanding provides …

One of the major disappointments in human autoimmunity has been the relative failure on
genome-wide association studies to provide “smoking genetic guns” that would explain the …

Autoimmune diseases occur when the immune system loses tolerance to self-antigens,
inducing inflammation and tissue damage. The pathogenesis of autoimmune diseases has …

Epigenetic mechanisms are essential for normal development and function of the immune
system. Similarly, a failure to maintain epigenetic homeostasis in the immune response due …

Autoimmune diseases are characterized by aberrant immune responses against healthy
cells and tissues, in which a given individual's genetic susceptibilities play a central role; …