In this article, we present results of our experimental and atomistic simulation studies of the
pH-dependent protonation behaviors of poly (2-(dimethylamino) ethyl methacrylate) …

The success of polyethyleneimine (PEI) as a nonviral-based gene delivery vector has been
attributed to its proton buffering capacity. Despite the great interest in PEI for its use in …

Linear PEI is a cationic polymer commonly used for complexing DNA into nanoparticles for
cell-transfection and gene-therapy applications. The polymer has closely-spaced amines …

Thestepwise protonation of three polymericamines, containing a different shieldinggroup
between the amine moieties of the repeating units, has been studied from a thermodynamic …

A number of water-soluble cationic carriers was evaluated as transfectant. Almost all studied
cationic methacrylate/methacrylamide polymers were able to condense the structure of …

One of the crucial steps in gene delivery with cationic polymers is the escape of the
polymer/DNA complexes (“polyplexes”) from the endosome. A possible way to enhance …

Polyethylenimine (PEI) is a highly studied vector for nonviral gene delivery, with a high
transfection efficiency that has been linked with its pH responsiveness. Atomistic molecular …

The optimization of DNA− cationic polymer complexation is crucial for nonviral gene
delivery. Although physicochemical characterization of the interaction between DNA and …

Classical molecular dynamics (MD) simulations were conducted for PNIPAM in 1 M
monovalent alkali chloride salt solutions as well as in 0.5 M divalent Mg2+ and Ca2+ …

Bioresponsive poly (amidoamine) s (PAA) s are currently under development as
endosomolytic polymers for intracellular delivery of proteins and genes. Here for the first …