A surprisingly large and unrelated number of human tumors depend on sustained
HEDGEHOG-GLI (HH-GLI) signaling for growth. This includes cancers of the skin, brain …

The current concept of tumourigenesis holds that cancer results from the progressive
acquisition of mutations that endow affected cells with selective growth advantages by …

Canonical Hedgehog (HH) signaling leads to the regulation of the GLI code: the sum of all
positive and negative functions of all GLI proteins. In humans, the three GLI factors encode …

The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical
role in controlling cell specification, cell–cell interaction and tissue patterning during …

A surprising number of apparently unrelated human diseases, including familial and
sporadic cancers and a number of syndromes and malformations, seem to be associated …

GLI transcription factors constitute the final effectors of the Hedgehog (HH) signaling
pathway. In many tumors, such as those of the pancreas, prostate, skin or lung, ectopic …

Simple Summary The Hedgehog/GLI (Hh/GLI) pathway plays a major role during
development and it is commonly dysregulated in many diseases, including cancer. This …

The HEDGEHOG-GLI (HH-GLI) signalling is a key pathway critical in embryonic
development, stem cell biology and tissue homeostasis. In recent years, aberrant activation …

The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a
consequence of improper control, aberrant HH signaling results in tumorigenesis and …

The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act
together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling …