Aging is the greatest risk factor for a multitude of diseases including cardiovascular disease,
neurodegeneration and cancer. Despite decades of research dedicated to understanding …

The free radical theory of aging posits that aging is caused by accumulation of damage
inflicted by reactive oxygen species (ROS). Although this concept has been very useful in …

Various nutritional, behavioral, and pharmacological interventions have been previously
shown to extend life span in diverse model organisms, including Saccharomyces cerevisiae …

Significance: The free radical theory of aging has provided a theoretical framework for an
enormous amount of work leading to significant advances in our understanding of aging. Up …

The free radical theory of aging states that aging results from the accumulated damage
caused by reactive oxygen species (ROS). Herein, we provide a critique of the theory that …

Significant advances in maintaining health throughout life can be made through a clear
understanding of the fundamental mechanisms that regulate aging. The Oxidative Stress …

Aging is an inherently complex process that is manifested within an organism at genetic,
molecular, cellular, organ, and system levels. Although the fundamental mechanisms are …

The Free Radical/Oxidative Stress Theory of Aging, which was first proposed in 1956, is
currently one of the most popular explanations for how aging occurs at the …

Research on the role of reactive oxygen species (ROS) in the aging process has advanced
significantly over the last two decades. In light of recent findings, ROS takes part in the aging …

Most organisms experience progressive declines in physiological function as they age.
Since this senescence of function is thought to underlie the decrease in quality of life in …