Intrauterine development is crucial for life-long health; therefore, elucidation of its key
regulators is of interest for their potential prognostic and therapeutic implications. Originally …

Introduction An aging-suppressor gene, klotho, is a candidate factor for vascular disease
because its deficiency leads to impaired endothelium-dependent vasodilation and impaired …

Klotho deficiency is a characteristic feature of chronic kidney disease in which anemia and
cardiovascular complications are prevalent. Disruption of the Klotho gene in mice results in …

Background Klotho gene was identified as an aging suppressor. In animals, klotho
overexpression extends life span, and defective klotho results in rapid aging and early …

Klotho-deficient mice have accelerated aging phenotypes, whereas overexpression of
Klotho in mice extends lifespan. Klotho is an anti-aging single-pass membrane protein …

Klotho is a critical protein that protects the kidney. Klotho is severely downregulated in
chronic kidney disease (CKD), and its deficiency is implicated in the pathogenesis and …

Klotho is a single‐pass transmembrane protein predominantly expressed in the kidney. The
extracellular domain of Klotho is subject to ectodomain shedding and is released into the …

The year 2017 marked the 20th anniversary of the first publication describing Klotho. This
single protein was and is remarkable in that its absence in mice conferred an accelerated …

Klotho, named after the ancient Greek goddess Klotho, the spinner (of life), is an aging
suppressor or longevity-related gene, discovered in 1997. A defect in the Klotho gene …

Klotho is highly expressed in the kidney and a soluble form of Klotho functions as an
endocrine substance that exerts multiple actions including the modulation of renal solute …