[HTML][HTML] The glutathione system: a journey from cyanobacteria to higher eukaryotes

C Cassier-Chauvat, F Marceau, S Farci, S Ouchane… - Antioxidants, 2023 - mdpi.com
From bacteria to plants and humans, the glutathione system plays a pleiotropic role in cell
defense against metabolic, oxidative and metal stresses. Glutathione (GSH), the γ-L …

Glutathione, an antioxidant tripeptide: dual roles in carcinogenesis and chemoprevention

A Narayanankutty, JT Job… - Current Protein and …, 2019 - ingentaconnect.com
Glutathione (GSH or reduced glutathione) is a tripeptide of gamma-Glutamyl-
cysteinylglycine and the predominant intracellular antioxidant in many organisms including …

Glutathione and glutaredoxin—key players in cellular redox homeostasis and signaling

YC Chai, JJ Mieyal - Antioxidants, 2023 - mdpi.com
This Special Issue of Antioxidants on Glutathione (GSH) and Glutaredoxin (Grx) was
designed to collect review articles and original research studies focused on advancing the …

Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress

JD Hayes, LI McLellan - Free radical research, 1999 - Taylor & Francis
Increases in the intracellular levels of reactive oxygen species (ROS), frequently referred to
as oxidative stress, respresents a potentially toxic insult which if not counteracted will lead to …

The many faces of glutathione in bacteria

L Masip, K Veeravalli, G Georgiou - Antioxidants & redox signaling, 2006 - liebertpub.com
Glutathione is one of the most abundant thiols present in cyanobacteria and proteobacteria,
and in all mitochondria or chloroplast-bearing eukaryotes. In bacteria, in addition to its key …

Glutathione: Role in oxidative/nitrosative stress, antioxidant defense, and treatments

S Raj Rai, C Bhattacharyya, A Sarkar… - …, 2021 - Wiley Online Library
Glutathione (GSH) is the most abundant cellular tripeptide (L‐γ‐glutamate‐L‐cysteinyl‐
glycine) which is as critical as oxygen and water. This low molecular mass antioxidant has a …

[HTML][HTML] Glutathione: new roles in redox signaling for an old antioxidant

K Aquilano, S Baldelli, MR Ciriolo - Frontiers in pharmacology, 2014 - frontiersin.org
The physiological roles played by the tripeptide glutathione have greatly advanced over the
past decades superimposing the research on free radicals, oxidative stress and, more …

[HTML][HTML] Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation

CA Labarrere, GS Kassab - Frontiers in Nutrition, 2022 - frontiersin.org
Many local and systemic diseases especially diseases that are leading causes of death
globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart …

Metabolism and functions of glutathione in micro-organisms

MJ Penninckx, MT Elskens - Advances in microbial physiology, 1993 - Elsevier
Publisher Summary The chapter discusses the biologically relevant chemistry of glutathione
(GSH) and its occurrence in microbial cells. The GSH-related biochemical reactions and the …

Glutathione homeostasis and functions: potential targets for medical interventions

VI Lushchak - Journal of amino acids, 2012 - Wiley Online Library
Glutathione (GSH) is a tripeptide, which has many biological roles including protection
against reactive oxygen and nitrogen species. The primary goal of this paper is to …